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Toll-like receptor induced pro-interleukin-1beta and interleukin-6 in monocytes are lower in healthy infants compared to adults

dc.contributor.authorLibraty, Daniel H.
dc.contributor.authorZhang, Lei
dc.contributor.authorWoda, Marcia
dc.contributor.authorAcosta, Luz P.
dc.contributor.authorObcena, Anamae
dc.contributor.authorBrion, Job D.
dc.contributor.authorCapeding, Rosario Z.
dc.date2022-08-11T08:09:41.000
dc.date.accessioned2022-08-23T16:40:05Z
dc.date.available2022-08-23T16:40:05Z
dc.date.issued2013-10-25
dc.date.submitted2014-02-07
dc.identifier.citationLibraty DH, Zhang L, Woda M, Acosta LP, Obcena A, et al. (2013) Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults. PLoS ONE 8(10): e78018. doi:10.1371/journal.pone.0078018 <a href="http://dx.doi.org/10.1371/journal.pone.0078018">Link to article on publisher's site</a>
dc.identifier.issn1932-6203 (Linking)
dc.identifier.doi10.1371/journal.pone.0078018
dc.identifier.pmid24205068
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39611
dc.description.abstractInfants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1beta and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-alpha. Lower TLR-induced production of pro-IL-1beta and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24205068&dopt=Abstract">Link to Article in PubMed</a>
dc.rights<p>Copyright 2013 Libraty et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p>
dc.subjectImmunity
dc.subjectImmunology of Infectious Disease
dc.titleToll-like receptor induced pro-interleukin-1beta and interleukin-6 in monocytes are lower in healthy infants compared to adults
dc.typeJournal Article
dc.source.journaltitlePloS one
dc.source.volume8
dc.source.issue10
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3403&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2403
dc.identifier.contextkey5082683
refterms.dateFOA2022-08-23T16:40:05Z
html.description.abstract<p>Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1beta and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-alpha. Lower TLR-induced production of pro-IL-1beta and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.</p>
dc.identifier.submissionpathoapubs/2403
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pagese78018


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