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dc.contributor.authorWatt, Torquil
dc.contributor.authorGroenvold, Mogens
dc.contributor.authorDeng, Nina
dc.contributor.authorGandek, Barbara
dc.contributor.authorFeldt-Rasmussen, Ulla
dc.contributor.authorRasmussen, Ase
dc.contributor.authorHegedus, Laszlo
dc.contributor.authorBonnema, Steen
dc.contributor.authorBjorner, Jakob
dc.date2022-08-11T08:09:41.000
dc.date.accessioned2022-08-23T16:40:16Z
dc.date.available2022-08-23T16:40:16Z
dc.date.issued2014-09-10
dc.date.submitted2014-11-14
dc.identifier.citationHealth Qual Life Outcomes. 2014 Sep 10;12(1):126. <a href="http://dx.doi.org/10.1186/s12955-014-0126-z">Link to article on publisher's site</a>
dc.identifier.issn1477-7525 (Linking)
dc.identifier.doi10.1186/s12955-014-0126-z
dc.identifier.pmid25213857
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39647
dc.description.abstractBackground and aim. Thyroid diseases are prevalent and chronic. With treatment, quality of life is restored in most, but not all patients. Construct validity of the thyroid-related quality of life questionnaire, ThyPRO, has been established by multi-trait scaling, but not evaluated with more elaborate methods. The purpose of the present study was to evaluate dimensionality of the ThyPRO scales and to attempt to understand possible item misfit through structural equation modeling for categorical data. Methods. The current 84-item version of ThyPRO consists of 13 scales, covering domains of physical (4 scales) and mental (2 scales) symptoms, function and well-being (3 scales) and participation/social function (4 scales). The data were collected from a cross-sectional sample of 907 thyroid patients. One-factor confirmatory models were fitted to each scale, and evaluated by model fit statistics (comparative fit index > 0.95, root mean square error of approximation < 0.08), magnitude of factor loadings, model residual correlations and modification indices (MI). Indications of multi-dimensionality were tested in bi-factor models. Possible item misfit was evaluated in a combined, investigational model. Results. Each ThyPRO scale was adequately represented by a unidimensional model after minor revisions. Eleven items were identified in the unidimensional models as potentially misfitting and were investigated further by multidimensional modeling. Conclusion. Elaborate psychometric modeling supported the construct validity of the ThyPRO. However, 11 potentially misfitting items and 18 items with local dependence to other items are candidates for removal in future item reduction processes.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25213857&dopt=Abstract">Link to Article in PubMed</a>
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEndocrine System Diseases
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectHealth Services Research
dc.titleConfirmatory factor analysis of the thyroid-related quality of life questionnaire ThyPRO
dc.typeJournal Article
dc.source.journaltitleHealth and quality of life outcomes
dc.source.volume12
dc.source.issue1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3446&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2446
dc.identifier.contextkey6359762
refterms.dateFOA2022-08-23T16:40:16Z
html.description.abstract<p>Background and aim. Thyroid diseases are prevalent and chronic. With treatment, quality of life is restored in most, but not all patients. Construct validity of the thyroid-related quality of life questionnaire, ThyPRO, has been established by multi-trait scaling, but not evaluated with more elaborate methods. The purpose of the present study was to evaluate dimensionality of the ThyPRO scales and to attempt to understand possible item misfit through structural equation modeling for categorical data.</p> <p>Methods. The current 84-item version of ThyPRO consists of 13 scales, covering domains of physical (4 scales) and mental (2 scales) symptoms, function and well-being (3 scales) and participation/social function (4 scales). The data were collected from a cross-sectional sample of 907 thyroid patients. One-factor confirmatory models were fitted to each scale, and evaluated by model fit statistics (comparative fit index > 0.95, root mean square error of approximation < 0.08), magnitude of factor loadings, model residual correlations and modification indices (MI). Indications of multi-dimensionality were tested in bi-factor models. Possible item misfit was evaluated in a combined, investigational model.</p> <p>Results. Each ThyPRO scale was adequately represented by a unidimensional model after minor revisions. Eleven items were identified in the unidimensional models as potentially misfitting and were investigated further by multidimensional modeling.</p> <p>Conclusion. Elaborate psychometric modeling supported the construct validity of the ThyPRO. However, 11 potentially misfitting items and 18 items with local dependence to other items are candidates for removal in future item reduction processes.</p>
dc.identifier.submissionpathoapubs/2446
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages126


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