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Except where otherwise noted, this item's license is described as <p>© 2015 Friedman and Rando; Published by Cold Spring Harbor Laboratory Press. This article, published in <em>Genome Research</em>, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at <a href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</a>.</p>