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Epigenomics and the structure of the living genome

dc.contributor.authorFriedman, Nir
dc.contributor.authorRando, Oliver J.
dc.date2022-08-11T08:09:43.000
dc.date.accessioned2022-08-23T16:41:02Z
dc.date.available2022-08-23T16:41:02Z
dc.date.issued2015-10-01
dc.date.submitted2015-10-29
dc.identifier.citationGenome Res. 2015 Oct;25(10):1482-90. doi: 10.1101/gr.190165.115. <a href="http://dx.doi.org/10.1101/gr.190165.115">Link to article on publisher's site</a>
dc.identifier.issn1088-9051 (Linking)
dc.identifier.doi10.1101/gr.190165.115
dc.identifier.pmid26430158
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39800
dc.description.abstractEukaryotic genomes are packaged into an extensively folded state known as chromatin. Analysis of the structure of eukaryotic chromosomes has been revolutionized by development of a suite of genome-wide measurement technologies, collectively termed "epigenomics." We review major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding at scales ranging from whole chromosome folding down to nucleotide-resolution assays that provide structural insights into protein-DNA interactions. We then briefly outline several challenges remaining and highlight new developments such as single-cell epigenomic assays that will help provide us with a high-resolution structural understanding of eukaryotic genomes.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26430158&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579333/
dc.rights<p>© 2015 Friedman and Rando; Published by Cold Spring Harbor Laboratory Press. This article, published in <em>Genome Research</em>, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at <a href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</a>.</p>
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectGenomics
dc.titleEpigenomics and the structure of the living genome
dc.typeJournal Article
dc.source.journaltitleGenome research
dc.source.volume25
dc.source.issue10
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3601&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2597
dc.identifier.contextkey7779454
refterms.dateFOA2022-08-23T16:41:02Z
html.description.abstract<p>Eukaryotic genomes are packaged into an extensively folded state known as chromatin. Analysis of the structure of eukaryotic chromosomes has been revolutionized by development of a suite of genome-wide measurement technologies, collectively termed "epigenomics." We review major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding at scales ranging from whole chromosome folding down to nucleotide-resolution assays that provide structural insights into protein-DNA interactions. We then briefly outline several challenges remaining and highlight new developments such as single-cell epigenomic assays that will help provide us with a high-resolution structural understanding of eukaryotic genomes.</p>
dc.identifier.submissionpathoapubs/2597
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.source.pages1482-90


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<p>© 2015 Friedman and Rando; Published by Cold Spring Harbor Laboratory Press. This article, published in <em>Genome Research</em>, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at <a href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</a>.</p>
Except where otherwise noted, this item's license is described as <p>© 2015 Friedman and Rando; Published by Cold Spring Harbor Laboratory Press. This article, published in <em>Genome Research</em>, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at <a href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</a>.</p>