Show simple item record

dc.contributor.authorWu, Tuoqi
dc.contributor.authorShin, HyunMu
dc.contributor.authorMoseman, E. Ashley
dc.contributor.authorJi, Yun
dc.contributor.authorHuang, Bonnie
dc.contributor.authorHarly, Christelle
dc.contributor.authorSen, Jyoti M.
dc.contributor.authorBerg, Leslie J.
dc.contributor.authorGattinoni, Luca
dc.contributor.authorMcGavern, Dorian B.
dc.contributor.authorSchwartzberg, Pamela L.
dc.date2022-08-11T08:09:43.000
dc.date.accessioned2022-08-23T16:41:04Z
dc.date.available2022-08-23T16:41:04Z
dc.date.issued2015-09-29
dc.date.submitted2015-10-29
dc.identifier.citationCell Rep. 2015 Sep 29;12(12):2099-110. doi: 10.1016/j.celrep.2015.08.049. Epub 2015 Sep 10. <a href="http://dx.doi.org/10.1016/j.celrep.2015.08.049">Link to article on publisher's site</a>
dc.identifier.issn2211-1247 (Electronic)
dc.identifier.doi10.1016/j.celrep.2015.08.049
dc.identifier.pmid26365183
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39807
dc.description.abstractT follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanisms that govern the differentiation and maintenance of these two distinct lineages during viral infection remain unclear. We found that viral-specific TFH and Th1 cells showed reciprocal expression of the transcriptions factors TCF1 and Blimp1 early after infection, even before the differential expression of the canonical TFH marker CXCR5. Furthermore, TCF1 was intrinsically required for the TFH cell response to viral infection; in the absence of TCF1, the TFH cell response was severely compromised, and the remaining TCF1-deficient TFH cells failed to maintain TFH-associated transcriptional and metabolic signatures, which were distinct from those in Th1 cells. Mechanistically, TCF1 functioned through forming negative feedback loops with IL-2 and Blimp1. Our findings demonstrate an essential role of TCF1 in TFH cell responses to viral infection.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26365183&dopt=Abstract">Link to Article in PubMed</a>
dc.rights<p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</p>
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCellular and Molecular Physiology
dc.subjectImmunology and Infectious Disease
dc.subjectImmunopathology
dc.subjectVirology
dc.titleTCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection
dc.typeJournal Article
dc.source.journaltitleCell reports
dc.source.volume12
dc.source.issue12
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3607&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2603
dc.identifier.contextkey7779460
refterms.dateFOA2022-08-23T16:41:04Z
html.description.abstract<p>T follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanisms that govern the differentiation and maintenance of these two distinct lineages during viral infection remain unclear. We found that viral-specific TFH and Th1 cells showed reciprocal expression of the transcriptions factors TCF1 and Blimp1 early after infection, even before the differential expression of the canonical TFH marker CXCR5. Furthermore, TCF1 was intrinsically required for the TFH cell response to viral infection; in the absence of TCF1, the TFH cell response was severely compromised, and the remaining TCF1-deficient TFH cells failed to maintain TFH-associated transcriptional and metabolic signatures, which were distinct from those in Th1 cells. Mechanistically, TCF1 functioned through forming negative feedback loops with IL-2 and Blimp1. Our findings demonstrate an essential role of TCF1 in TFH cell responses to viral infection.</p>
dc.identifier.submissionpathoapubs/2603
dc.contributor.departmentDepartment of Pathology
dc.source.pages2099-110


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
1_s2.0_S2211124715009468_main.pdf
Size:
3.336Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

<p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</p>
Except where otherwise noted, this item's license is described as <p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</p>