Protein conformation in a vaccine matters
UMass Chan Affiliations
Department of Microbiology and Physiological SystemsDocument Type
EditorialPublication Date
2015-09-08Keywords
Immunology and Microbiology SectionImmune response
Immunity
protein conformation
respiratory syncytial virus
vaccine
fusion protein
Biochemistry
Immunity
Immunology of Infectious DiseaseImmunoprophylaxis and TherapyStructural BiologyVirologyVirus Diseases
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Show full item recordAbstract
Virus-like particles (VLPs) are increasingly being considered as vaccine candidates for a variety of human and animal pathogens. Our results demonstrate that the conformation of antigens in VLPs is of critical importance for optimal stimulation of protective as well as durable immune responses.Source
Oncotarget. 2015 Sep 8;6(26):21781-2. DOI: 10.18632/oncotarget.5102. Link to article on publisher's websiteDOI
10.18632/oncotarget.5102Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39814PubMed ID
26318167Related Resources
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