Webber, Matthew J.
Tang, Benjamin C.
Lavin, Danya M.
Doloff, Joshua C.
Greiner, Dale L.
Newburger, Peter E.
von Andrian, Ulrich H.
Anderson, Daniel G.
UMass Chan AffiliationsDepartment of Pediatrics, Division of Hematology/Oncology
Diabetes Center of Excellence
Department of Molecular Medicine
Document TypeJournal Article
KeywordsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
MetadataShow full item record
AbstractIn vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of the first immune cells to be recruited to implantation sites, have been suggested to contribute to the establishment of the inflammatory microenvironment that initiates the fibrotic response. However, the precise numbers and roles of neutrophils in response to implanted devices remains unclear. Using a mouse model of peritoneal microcapsule implantation, we show 30-500 fold increased neutrophil presence in the peritoneal exudates in response to implants. We demonstrate that these neutrophils secrete increased amounts of a variety of inflammatory cytokines and chemokines. Further, we observe that they participate in the foreign body response through the formation of neutrophil extracellular traps (NETs) on implant surfaces. Our results provide new insight into neutrophil function during a foreign body response to peritoneal implants which has implications for the development of biologically compatible medical devices.
SourcePLoS One. 2015 Sep 10;10(9):e0137550. doi: 10.1371/journal.pone.0137550. eCollection 2015. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/39841
Related ResourcesLink to Article in PubMed
Copyright: 2015 Jhunjhunwala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited