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dc.contributor.authorCraig, Daniel M.
dc.contributor.authorAshcroft, Stephen P.
dc.contributor.authorBelew, Micah Y.
dc.contributor.authorStocks, Ben
dc.contributor.authorCurrell, Kevin
dc.contributor.authorBaar, Keith
dc.contributor.authorPhilp, Andrew
dc.date2022-08-11T08:09:44.000
dc.date.accessioned2022-08-23T16:41:25Z
dc.date.available2022-08-23T16:41:25Z
dc.date.issued2015-10-27
dc.date.submitted2016-01-15
dc.identifier.citationFront Physiol. 2015 Oct 27;6:296. doi: 10.3389/fphys.2015.00296. eCollection 2015. <a href="http://dx.doi.org/10.3389/fphys.2015.00296">Link to article on publisher's site</a>
dc.identifier.issn1664-042X (Linking)
dc.identifier.doi10.3389/fphys.2015.00296
dc.identifier.pmid26578969
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39881
dc.description.abstractEndurance exercise, when performed regularly as part of a training program, leads to increases in whole-body and skeletal muscle-specific oxidative capacity. At the cellular level, this adaptive response is manifested by an increased number of oxidative fibers (Type I and IIA myosin heavy chain), an increase in capillarity and an increase in mitochondrial biogenesis. The increase in mitochondrial biogenesis (increased volume and functional capacity) is fundamentally important as it leads to greater rates of oxidative phosphorylation and an improved capacity to utilize fatty acids during sub-maximal exercise. Given the importance of mitochondrial biogenesis for skeletal muscle performance, considerable attention has been given to understanding the molecular cues stimulated by endurance exercise that culminate in this adaptive response. In turn, this research has led to the identification of pharmaceutical compounds and small nutritional bioactive ingredients that appear able to amplify exercise-responsive signaling pathways in skeletal muscle. The aim of this review is to discuss these purported exercise mimetics and bioactive ingredients in the context of mitochondrial biogenesis in skeletal muscle. We will examine proposed modes of action, discuss evidence of application in skeletal muscle in vivo and finally comment on the feasibility of such approaches to support endurance-training applications in humans.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26578969&dopt=Abstract">Link to Article in PubMed</a>
dc.rights<p>Copyright © 2015 Craig, Ashcroft, Belew, Stocks, Currell, Baar and Philp. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution License (CC BY)</a>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbioactives
dc.subjectexercise mimetics
dc.subjectmitochondrial biogenesis
dc.subjectnutraceuticals
dc.subjectskeletal muscle
dc.subjectCellular and Molecular Physiology
dc.subjectExercise Physiology
dc.titleUtilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis
dc.typeJournal Article
dc.source.journaltitleFrontiers in physiology
dc.source.volume6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3687&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2683
dc.identifier.contextkey8015336
refterms.dateFOA2022-08-23T16:41:26Z
html.description.abstract<p>Endurance exercise, when performed regularly as part of a training program, leads to increases in whole-body and skeletal muscle-specific oxidative capacity. At the cellular level, this adaptive response is manifested by an increased number of oxidative fibers (Type I and IIA myosin heavy chain), an increase in capillarity and an increase in mitochondrial biogenesis. The increase in mitochondrial biogenesis (increased volume and functional capacity) is fundamentally important as it leads to greater rates of oxidative phosphorylation and an improved capacity to utilize fatty acids during sub-maximal exercise. Given the importance of mitochondrial biogenesis for skeletal muscle performance, considerable attention has been given to understanding the molecular cues stimulated by endurance exercise that culminate in this adaptive response. In turn, this research has led to the identification of pharmaceutical compounds and small nutritional bioactive ingredients that appear able to amplify exercise-responsive signaling pathways in skeletal muscle. The aim of this review is to discuss these purported exercise mimetics and bioactive ingredients in the context of mitochondrial biogenesis in skeletal muscle. We will examine proposed modes of action, discuss evidence of application in skeletal muscle in vivo and finally comment on the feasibility of such approaches to support endurance-training applications in humans.</p>
dc.identifier.submissionpathoapubs/2683
dc.contributor.departmentDepartment of Molecular, Cell and Cancer Biology
dc.source.pages296
dc.contributor.studentMicah Belew
dc.description.thesisprogramInterdisciplinary


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<p>Copyright © 2015 Craig, Ashcroft, Belew, Stocks, Currell, Baar and Philp. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution License (CC BY)</a>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
Except where otherwise noted, this item's license is described as <p>Copyright © 2015 Craig, Ashcroft, Belew, Stocks, Currell, Baar and Philp. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution License (CC BY)</a>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>