Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
UMass Chan AffiliationsDepartment of Biochemistry and Molecular Pharmacology
Document TypeJournal Article
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AbstractDendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1. Analysis of the TIA1 interactome in brain tissue from wild-type (WT) and tau knockout mice demonstrates that tau is required for normal interactions of TIA1 with proteins linked to RNA metabolism, including ribosomal proteins and RBPs. Expression studies show that tau regulates the distribution of TIA1, and tau accelerates stress granule (SG) formation. Conversely, TIA1 knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 induces tau misfolding and stimulates neurodegeneration. Pharmacological interventions that prevent SG formation also inhibit tau pathophysiology. These studies suggest that the pathophysiology of tauopathy requires an intimate interaction with RNA-binding proteins.
SourceCell Rep. 2016 May 17;15(7):1455-66. doi: 10.1016/j.celrep.2016.04.045. Epub 2016 May 6. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/40030
Full author list omitted for brevity. For full list of authors see article.
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RightsUnder a Creative Commons license, http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as Under a Creative Commons license, http://creativecommons.org/licenses/by/4.0/.