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dc.contributor.authorFreedman, Jane E.
dc.contributor.authorMick, Eric O.
dc.contributor.authorBeaulieu, Lea M.
dc.contributor.authorTanriverdi, Selim E.
dc.contributor.authorKoupenova-Zamor, Milka
dc.contributor.authorMikhalev, Ekaterina
dc.contributor.authorTanriverdi, Kahraman
dc.date2022-08-11T08:09:45.000
dc.date.accessioned2022-08-23T16:42:13Z
dc.date.available2022-08-23T16:42:13Z
dc.date.issued2016-04-26
dc.date.submitted2016-08-16
dc.identifier.citationNat Commun. 2016 Apr 26;7:11106. doi: 10.1038/ncomms11106. <a href="http://dx.doi.org/10.1038/ncomms11106">Link to article on publisher's site</a>
dc.identifier.issn2041-1723 (Linking)
dc.identifier.doi10.1038/ncomms11106
dc.identifier.pmid27112789
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40048
dc.description<p>Full author list omitted for brevity. For full list of authors see article.</p>
dc.description.abstractThere is growing appreciation for the importance of non-protein-coding genes in development and disease. Although much is known about microRNAs, limitations in bioinformatic analyses of RNA sequencing have precluded broad assessment of other forms of small-RNAs in humans. By analysing sequencing data from plasma-derived RNA from 40 individuals, here we identified over a thousand human extracellular RNAs including microRNAs, piwi-interacting RNA (piRNA), and small nucleolar RNAs. Using a targeted quantitative PCR with reverse transcription approach in an additional 2,763 individuals, we characterized almost 500 of the most abundant extracellular transcripts including microRNAs, piRNAs and small nucleolar RNAs. The presence in plasma of many non-microRNA small-RNAs was confirmed in an independent cohort. We present comprehensive data to demonstrate the broad and consistent detection of diverse classes of circulating non-cellular small-RNAs from a large population.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27112789&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGenetics
dc.subjectSmall RNAs
dc.subjectComputational Biology
dc.subjectGenetics
dc.subjectGenomics
dc.subjectHemic and Immune Systems
dc.titleDiverse human extracellular RNAs are widely detected in human plasma
dc.typeJournal Article
dc.source.journaltitleNature communications
dc.source.volume7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3858&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2853
dc.identifier.contextkey8985397
refterms.dateFOA2022-08-23T16:42:13Z
html.description.abstract<p>There is growing appreciation for the importance of non-protein-coding genes in development and disease. Although much is known about microRNAs, limitations in bioinformatic analyses of RNA sequencing have precluded broad assessment of other forms of small-RNAs in humans. By analysing sequencing data from plasma-derived RNA from 40 individuals, here we identified over a thousand human extracellular RNAs including microRNAs, piwi-interacting RNA (piRNA), and small nucleolar RNAs. Using a targeted quantitative PCR with reverse transcription approach in an additional 2,763 individuals, we characterized almost 500 of the most abundant extracellular transcripts including microRNAs, piRNAs and small nucleolar RNAs. The presence in plasma of many non-microRNA small-RNAs was confirmed in an independent cohort. We present comprehensive data to demonstrate the broad and consistent detection of diverse classes of circulating non-cellular small-RNAs from a large population.</p>
dc.identifier.submissionpathoapubs/2853
dc.contributor.departmentUMass Metabolic Network
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages11106


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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/