Authors
Patel, Avni V.Miller, John B.
Nath, Rajneesh
Shih, Helen A.
Yoon, Michael K.
Freitag, Suzanne K.
Papaliodis, George
Chen, Teresa C.
Eliott, Dean
Kim, Ivana K.
UMass Chan Affiliations
Department of Medicine, Division of Hematology/OncologyDocument Type
Journal ArticlePublication Date
2016-04-01Keywords
Choroidal infiltrationLeukemia
Ocular manifestations of leukemia
Ocular oncology
Radiation
Hematology
Hemic and Lymphatic Diseases
Neoplasms
Oncology
Metadata
Show full item recordAbstract
BACKGROUND/AIM: Unilateral choroidal infiltration as the initial manifestation of leukemic relapse in adults is rare, particularly after an extended period of remission. This report describes this unique ophthalmic presentation, highlights the associated diagnostic challenges, and reviews the literature. METHODS: Two cases are described and an extensive literature review was conducted. RESULTS: A 59-year-old male with acute lymphoid leukemia, in remission for 18 months, presented with unilateral scleritis, exudative retinal detachment, and choroidal thickening. A 57-year-old male with a history of acute myeloid leukemia, in remission for 4 years, presented with unilateral choroidal thickening leading to secondary angle closure. In both cases, there was a significant lag from the onset of eye symptoms to establishing a systemic diagnosis of acute leukemia, leading to a delay in definitive systemic treatment, despite a high suspicion of disease based on ophthalmic findings. CONCLUSIONS: These two cases illustrate the fundus findings consistent with leukemic choroidal infiltration that can represent the first sign of relapsed leukemia. The successful treatment of these patients hinges on collaboration between ophthalmologists and oncologists to optimize patient outcomes, highlighting the need for both groups to be aware of this rare ophthalmic presentation.Source
Ocul Oncol Pathol. 2016 Apr;2(3):166-70. doi: 10.1159/000442951. Epub 2016 Jan 13. Link to article on publisher's siteDOI
10.1159/000442951Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40070PubMed ID
27239459Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1159/000442951