Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
Gerstein, Mark B.
Mick, Eric O.
Freedman, Jane E.
UMass Chan AffiliationsUMass Metabolic Network
Department of Quantitative Health Sciences
Department of Medicine, Division of Cardiovascular Medicine
Document TypeJournal Article
Nucleic Acids, Nucleotides, and Nucleosides
MetadataShow full item record
AbstractMicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.
SourcePLoS One. 2016 Apr 28;11(4):e0153691. doi: 10.1371/journal.pone.0153691. eCollection 2016. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/40107
Related ResourcesLink to Article in PubMed
RightsThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Except where otherwise noted, this item's license is described as This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.