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dc.contributor.authorShah, Ravi
dc.contributor.authorTanriverdi, Kahraman
dc.contributor.authorLevy, Daniel
dc.contributor.authorLarson, Martin
dc.contributor.authorGerstein, Mark B.
dc.contributor.authorMick, Eric O.
dc.contributor.authorRozowsky, Joel
dc.contributor.authorKitchen, Robert
dc.contributor.authorMurthy, Venkatesh
dc.contributor.authorMikalev, Ekaterina
dc.contributor.authorFreedman, Jane E.
dc.date2022-08-11T08:09:46.000
dc.date.accessioned2022-08-23T16:42:30Z
dc.date.available2022-08-23T16:42:30Z
dc.date.issued2016-04-28
dc.date.submitted2016-11-30
dc.identifier.citationPLoS One. 2016 Apr 28;11(4):e0153691. doi: 10.1371/journal.pone.0153691. eCollection 2016. <a href="http://dx.doi.org/10.1371/journal.pone.0153691">Link to article on publisher's site</a>
dc.identifier.issn1932-6203 (Linking)
dc.identifier.doi10.1371/journal.pone.0153691
dc.identifier.pmid27123852
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40107
dc.description.abstractMicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27123852&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectUMCCTS funding
dc.subjectMicroRNAs
dc.subjectBlood plasma
dc.subjectBlood
dc.subjectRNA isolation
dc.subjectBiomarkers
dc.subjectRNA sequencing
dc.subjectGene expression
dc.subjectGene regulation
dc.subjectBiological Factors
dc.subjectGenetic Processes
dc.subjectMedical Biochemistry
dc.subjectNucleic Acids, Nucleotides, and Nucleosides
dc.titleDiscordant Expression of Circulating microRNA from Cellular and Extracellular Sources
dc.typeJournal Article
dc.source.journaltitlePloS one
dc.source.volume11
dc.source.issue4
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3913&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2908
dc.identifier.contextkey9425546
refterms.dateFOA2022-08-23T16:42:30Z
html.description.abstract<p>MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.</p>
dc.identifier.submissionpathoapubs/2908
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pagese0153691


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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Except where otherwise noted, this item's license is described as This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.