Longitudinal changes in neurodevelopmental outcomes between 18 and 36 months in children with prenatal triptan exposure: findings from the Norwegian Mother and Child Cohort Study
UMass Chan Affiliations
Graduate School of Biomedical Sciences, Clinical and Population Health ResearchDepartment of Quantitative Health Sciences
Department of Psychiatry
Document Type
Journal ArticlePublication Date
2016-09-13Keywords
EpidemiologyMental health
medication use in pregnancy
Chemicals and Drugs
Clinical Epidemiology
Disorders of Environmental Origin
Environmental Public Health
Female Urogenital Diseases and Pregnancy Complications
Health Services Research
Maternal and Child Health
Medical Toxicology
Psychiatry and Psychology
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OBJECTIVE: This study sought to determine whether changes in neurodevelopmental outcomes between 18 and 36 months of age were associated with prenatal exposure to triptan medications, a class of 5-HT receptor agonists used in the treatment of migraine. METHOD: Using data from the Norwegian Mother and Child Cohort Study, a prospective birth cohort that includes nearly 40% of all pregnancies in Norway from 1999 to 2008, we identified 50 469 mother-child dyads who met inclusion criteria and were present for at least one follow-up assessment at 18 or 36 months postpartum. Neurodevelopment was assessed using the Child Behaviour Checklist, the Emotionality, Activity, and Shyness Questionnaire, and the Ages and Stages Questionnaire. We used generalised estimating equations to evaluate change from 18 to 36 months for children prenatally exposed to triptans, relative to contrast groups, and used marginal structural models with inverse probability of treatment and censoring weights to address time-varying exposure and confounding as well as loss to follow-up. RESULTS: Among eligible participants (n=50 469), 1.0% used a triptan during pregnancy, 2.0% used triptans prior to pregnancy only, 8.0% reported migraine without triptan use and 89.0% had no history of migraine. Children with prenatal triptan exposure had greater increases in emotionality (r-RR 2.18, 95% CI 1.03 to 4.53) and activity problems (r-RR 1.70, 95% CI 1.02 to 2.8) compared to children born to mothers who discontinued triptan use prior to pregnancy. CONCLUSION: Prenatal triptan exposure was associated with changes over time in externalising-type behaviours such as emotionality and activity, but not with internalising-type behaviours.Source
BMJ Open. 2016 Sep 13;6(9):e011971. doi: 10.1136/bmjopen-2016-011971. Link to article on publisher's siteDOI
10.1136/bmjopen-2016-011971Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40154PubMed ID
27625061Notes
Mollie E. Wood is a doctoral student in the Clinical and Population Health Research Program in the Graduate School of Biomedical Sciences at UMass Medical School.
Related Resources
Link to Article in PubMedDistribution License
http://creativecommons.org/licenses/by-nc/4.0/ae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2016-011971
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/