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dc.contributor.authorBrettler, Doreen B.
dc.contributor.authorMannucci, Pier Mannuccio
dc.contributor.authorGringeri, Alessandro
dc.contributor.authorRasko, John E. J.
dc.contributor.authorForsberg, Ann D.
dc.contributor.authorRumi, Maria Grazia
dc.contributor.authorGarsia, Roger J.
dc.contributor.authorRickard, Kathleen A.
dc.contributor.authorColombo, Massimo
dc.date2022-08-11T08:09:46.000
dc.date.accessioned2022-08-23T16:43:00Z
dc.date.available2022-08-23T16:43:00Z
dc.date.issued1992-07-15
dc.date.submitted2008-04-14
dc.identifier.citationBlood. 1992 Jul 15;80(2):540-3.
dc.identifier.issn0006-4971 (Print)
dc.identifier.pmid1627805
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40204
dc.description.abstractTo study the transmission rate of hepatitis C virus (HCV) in the female sexual partners of antibody-positive hemophilic males, 106 partners from three hemophilia centers located in Europe, America, and Australia were tested for HCV seropositivity using a first-generation enzyme-linked immunosorbent assay (ELISA-1) and, subsequently, a second-generation ELISA (ELISA-2) and a supplemental recombinant immunoblot assay. Additionally, the cohort was tested for the presence of antibody to the human immunodeficiency virus type-1 and hepatitis B virus markers. No female partner was HCV antibody-positive using the ELISA-1 test, whereas five were seropositive by the ELISA-2 test. Three of these five female partners were seropositive on the supplemental test, the remaining two having indeterminate results, for an overall prevalence of 2.7%. Thus, even with the use of sensitive testing, the prevalence of HCV infection remains low in this cohort, showing that the efficiency of heterosexual transmission of HCV is poor.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1627805&dopt=Abstract ">Link to article in PubMed</a></p>
dc.subjectBlood Transfusion
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHIV Antibodies
dc.subjectHIV Seropositivity
dc.subject*Hemophilia A
dc.subjectHepatitis Antibodies
dc.subjectHepatitis C
dc.subjectHumans
dc.subjectMale
dc.subjectRisk Factors
dc.subject*Sexual Behavior
dc.subjectHematology
dc.subjectOncology
dc.titleThe low risk of hepatitis C virus transmission among sexual partners of hepatitis C-infected hemophilic males: an international, multicenter study
dc.typeArticle
dc.source.journaltitleBlood
dc.source.volume80
dc.source.issue2
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1299&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/300
dc.identifier.contextkey489638
refterms.dateFOA2022-08-23T16:43:00Z
html.description.abstract<p>To study the transmission rate of hepatitis C virus (HCV) in the female sexual partners of antibody-positive hemophilic males, 106 partners from three hemophilia centers located in Europe, America, and Australia were tested for HCV seropositivity using a first-generation enzyme-linked immunosorbent assay (ELISA-1) and, subsequently, a second-generation ELISA (ELISA-2) and a supplemental recombinant immunoblot assay. Additionally, the cohort was tested for the presence of antibody to the human immunodeficiency virus type-1 and hepatitis B virus markers. No female partner was HCV antibody-positive using the ELISA-1 test, whereas five were seropositive by the ELISA-2 test. Three of these five female partners were seropositive on the supplemental test, the remaining two having indeterminate results, for an overall prevalence of 2.7%. Thus, even with the use of sensitive testing, the prevalence of HCV infection remains low in this cohort, showing that the efficiency of heterosexual transmission of HCV is poor.</p>
dc.identifier.submissionpathoapubs/300
dc.contributor.departmentDepartment of Medicine, Division of Hematology and Oncology
dc.source.pages540-3


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