Show simple item record

Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages

dc.contributor.authorSoto, Ernesto R.
dc.contributor.authorO'Connell, Olivia
dc.contributor.authorDikengil, Fusun
dc.contributor.authorPeters, Paul J.
dc.contributor.authorClapham, Paul R.
dc.contributor.authorOstroff, Gary R.
dc.date2022-08-11T08:09:46.000
dc.date.accessioned2022-08-23T16:43:02Z
dc.date.available2022-08-23T16:43:02Z
dc.date.issued2016-12-14
dc.date.submitted2017-04-14
dc.identifier.citationJ Drug Deliv. 2016;2016:8520629. Epub 2016 Nov 14. <a href="https://doi.org/10.1155/2016/8520629">Link to article on publisher's site</a>
dc.identifier.issn2090-3022 (Linking)
dc.identifier.doi10.1155/2016/8520629
dc.identifier.pmid27965897
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40211
dc.description.abstractGlucan particles (GPs) are hollow, porous 3-5 mum microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-beta-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing beta-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection. Here, macrophage targeting of gallium using GPs provides for more efficient delivery of gallium and inhibition of HIV infection in macrophages compared to free gallium nanoparticles.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27965897&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsCopyright © 2016 Ernesto R. Soto et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTherapeutics
dc.titleTargeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages
dc.typeJournal Article
dc.source.journaltitleJournal of drug delivery
dc.source.volume2016
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4011&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3006
dc.identifier.contextkey10021755
refterms.dateFOA2022-08-23T16:43:02Z
html.description.abstract<p>Glucan particles (GPs) are hollow, porous 3-5 mum microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-beta-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing beta-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection. Here, macrophage targeting of gallium using GPs provides for more efficient delivery of gallium and inhibition of HIV infection in macrophages compared to free gallium nanoparticles.</p>
dc.identifier.submissionpathoapubs/3006
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages8520629


Files in this item

Thumbnail
Name:
8520629.pdf
Size:
2.599Mb
Format:
PDF
Download

This item appears in the following Collection(s)

Show simple item record

Copyright © 2016 Ernesto R. Soto et al.
Except where otherwise noted, this item's license is described as Copyright © 2016 Ernesto R. Soto et al.