Longitudinal changes in the dietary inflammatory index: an assessment of the inflammatory potential of diet over time in postmenopausal women
Authors
Tabung, F. K.Steck, S. E.
Zhang, J.
Ma, Yunsheng
Liese, A. D.
Tylavsky, F. A.
Vitolins, M. Z.
Ockene, Judith K.
Hebert, J. R.
UMass Chan Affiliations
Prevention Research CenterDepartment of Medicine, Division of Preventive and Behavioral Medicine
Document Type
Journal ArticlePublication Date
2016-12-01Keywords
Dietetics and Clinical NutritionEpidemiology
Human and Clinical Nutrition
Nutritional Epidemiology
Women's Health
Metadata
Show full item recordAbstract
BACKGROUND/OBJECTIVES: The dietary inflammatory index (DII) measured at one time point is associated with risk of several chronic diseases, but disease risk may change with longitudinal changes in DII scores. Data are lacking regarding changes in DII scores over time; therefore, we assessed changes in the DII in the Women's Health Initiative (WHI). SUBJECTS/METHODS: DII scores were calculated using data from repeated food frequency questionnaires in the WHI Observational Study (OS; n=76 671) at baseline and year 3, and the WHI Dietary Modification trial (DM; n=48482) at three time points. Lower DII scores represent more anti-inflammatory diets. We used generalized estimating equations to compare mean changes in DII over time, adjusting for multiple comparisons, and multivariable-adjusted linear regression analyses to determine predictors of DII change. RESULTS: In the OS, mean DII decreased modestly from -1.14 at baseline to -1.50 at year 3. In the DM, DII was -1.32 in year 1, -1.60 in year 3 and -1.48 in year 6 in the intervention arm and was -0.65 in year 1, -0.94 in year 3 and -0.96 in year 6 in the control arm. These changes were modified by body mass index, education and race/ethnicity. A prediction model explained 22% of the variance in the change in DII scores in the OS. CONCLUSIONS: In this prospective investigation of postmenopausal women, reported dietary inflammatory potential decreased modestly over time. Largest reductions were observed in normal-weight, highly educated women. Future research is warranted to examine whether reductions in DII are associated with decreased chronic disease risk.Source
Eur J Clin Nutr. 2016 Dec;70(12):1374-1380. Epub 2016 Jul 6. Link to article on publisher's siteDOI
10.1038/ejcn.2016.116Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40232PubMed ID
27380883Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/ejcn.2016.116