Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Pazour, Gregory J.
Hsu, Victor W.
UMass Chan AffiliationsProgram in Molecular Medicine
Document TypeJournal Article
MetadataShow full item record
AbstractSignaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.
SourceSci Rep. 2017 Dec;7(1):1. doi: 10.1038/s41598-016-0028-x. Epub 2017 Jan 26. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/40245
Related ResourcesLink to Article in PubMed
RightsCopyright © The Author(s) 2017