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dc.contributor.authorKwon-Chung, Kyung J.
dc.contributor.authorLevitz, Stuart M.
dc.contributor.authorCasadevall, Arturo
dc.date2022-08-11T08:09:47.000
dc.date.accessioned2022-08-23T16:43:21Z
dc.date.available2022-08-23T16:43:21Z
dc.date.issued2017-01-11
dc.date.submitted2017-06-09
dc.identifier.citationmSphere. 2017 Jan 11;2(1). pii: e00357-16. eCollection 2017 Jan-Feb. <a href="https://doi.org/10.1128/mSphere.00357-16">Link to article on publisher's site</a>
dc.identifier.issn2379-5042 (Linking)
dc.identifier.doi10.1128/mSphere.00357-16
dc.identifier.pmid28101535
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40273
dc.description<p>Full author list omitted for brevity. For the full list of authors, see article.</p>
dc.description.abstractCryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii. Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using "Cryptococcus neoformans species complex" and "C. gattii species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28101535&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsCopyright © 2017 Kwon-Chung et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCryptococcosis
dc.subjectCryptococcus gattii
dc.subjectCryptococcus neoformans
dc.subjectclade
dc.subjectgenetic diversity
dc.subjectnew nomenclature
dc.subjectspecies complex
dc.subjectBiodiversity
dc.subjectEcology and Evolutionary Biology
dc.subjectMicrobiology
dc.titleThe Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis
dc.typeJournal Article
dc.source.journaltitlemSphere
dc.source.volume2
dc.source.issue1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4074&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3069
dc.identifier.contextkey10275046
refterms.dateFOA2022-08-23T16:43:21Z
html.description.abstract<p>Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii. Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using "Cryptococcus neoformans species complex" and "C. gattii species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.</p>
dc.identifier.submissionpathoapubs/3069
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology


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Copyright © 2017 Kwon-Chung et al.
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