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dc.contributor.authorLin, Honghuang
dc.contributor.authorYin, Xiaoyan
dc.contributor.authorXie, Zhijun
dc.contributor.authorLunetta, Kathryn L.
dc.contributor.authorLubitz, Steven A.
dc.contributor.authorLarson, Martin G.
dc.contributor.authorKo, Darae
dc.contributor.authorMagnani, Jared W.
dc.contributor.authorMendelson, Michael M.
dc.contributor.authorLiu, Chunyu
dc.contributor.authorMcManus, David D.
dc.contributor.authorLevy, Daniel
dc.contributor.authorEllinor, Patrick T.
dc.contributor.authorBenjamin, Emelia J.
dc.date2022-08-11T08:09:47.000
dc.date.accessioned2022-08-23T16:43:21Z
dc.date.available2022-08-23T16:43:21Z
dc.date.issued2017-01-09
dc.date.submitted2017-06-09
dc.identifier.citationSci Rep. 2017 Jan 9;7:40377. doi: 10.1038/srep40377. <a href="https://doi.org/10.1038/srep40377">Link to article on publisher's site</a>
dc.identifier.issn2045-2322 (Linking)
dc.identifier.doi10.1038/srep40377
dc.identifier.pmid28067321
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40275
dc.description.abstractAtrial fibrillation (AF) is the most common cardiac arrhythmia, but little is known about the molecular mechanisms associated with AF arrhythmogenesis. DNA methylation is an important epigenetic mechanism that regulates gene expression and downstream biological processes. We hypothesize that DNA methylation might play an important role in the susceptibility to develop AF. A total of 2,639 participants from the Offspring Cohort of Framingham Heart Study were enrolled in the current study. These participants included 183 participants with prevalent AF and 220 with incident AF during up to 9 years follow up. Genome-wide methylation was profiled using the Illumina Infinium HumanMethylation450 BeadChip on blood-derived DNA collected during the eighth examination cycle (2005-2008). Two CpG sites were significantly associated with prevalent AF, and five CpGs were associated with incident AF after correction for multiple testing (FDR < 0.05). Fourteen previously reported genome-wide significant AF-related SNP were each associated with at least one CpG site; the most significant association was rs6490029 at the CUX2 locus and cg10833066 (P = 9.5 x 10-279). In summary, we performed genome-wide methylation profiling in a community-based cohort and identified seven methylation signatures associated with AF. Our study suggests that DNA methylation might play an important role in AF arrhythmogenesis.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28067321&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsCopyright © 2017, The Author(s).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAtrial fibrillation
dc.subjectCardiovascular genetics
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectMolecular Biology
dc.subjectMolecular Genetics
dc.titleMethylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study
dc.typeJournal Article
dc.source.journaltitleScientific reports
dc.source.volume7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4078&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3073
dc.identifier.contextkey10275053
refterms.dateFOA2022-08-23T16:43:21Z
html.description.abstract<p>Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little is known about the molecular mechanisms associated with AF arrhythmogenesis. DNA methylation is an important epigenetic mechanism that regulates gene expression and downstream biological processes. We hypothesize that DNA methylation might play an important role in the susceptibility to develop AF. A total of 2,639 participants from the Offspring Cohort of Framingham Heart Study were enrolled in the current study. These participants included 183 participants with prevalent AF and 220 with incident AF during up to 9 years follow up. Genome-wide methylation was profiled using the Illumina Infinium HumanMethylation450 BeadChip on blood-derived DNA collected during the eighth examination cycle (2005-2008). Two CpG sites were significantly associated with prevalent AF, and five CpGs were associated with incident AF after correction for multiple testing (FDR < 0.05). Fourteen previously reported genome-wide significant AF-related SNP were each associated with at least one CpG site; the most significant association was rs6490029 at the CUX2 locus and cg10833066 (P = 9.5 x 10-279). In summary, we performed genome-wide methylation profiling in a community-based cohort and identified seven methylation signatures associated with AF. Our study suggests that DNA methylation might play an important role in AF arrhythmogenesis.</p>
dc.identifier.submissionpathoapubs/3073
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages40377


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