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    Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder

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    Authors
    Ferris, Craig F.
    Rasmussen, Mads F.
    Messenger, Tara L.
    Koppel, Gary A.
    UMass Chan Affiliations
    Program in Behavioral Neuroscience
    Document Type
    Journal Article
    Publication Date
    2001-09-08
    Keywords
    Adrenergic Uptake Inhibitors
    Aggression
    Animals
    Arginine Vasopressin
    Behavior, Animal
    Clomipramine
    Cricetinae
    Desipramine
    Dose-Response Relationship, Drug
    Fluoxetine
    Grooming
    Hair
    Hypothalamus
    Male
    Microinjections
    Obsessive-Compulsive Disorder
    Pigmentation
    Serotonin Agonists
    Serotonin Uptake Inhibitors
    Neuroscience and Neurobiology
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    Abstract
    BACKGROUND: Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin microinjections into the anterior hypothalamus trigger robust grooming and flank marking, a stereotyped scent marking behaviors. The intensity and repetition of the behaviors induced by arginine vasopressin is somewhat reminiscent of Obsessive Compulsive Disorder in humans. The present experiments were carried out to test whether pharmacological agents used to alleviate obsessive compulsive disorder could inhibit arginine vasopressin-induced flank marking and grooming. RESULTS: Male golden hamsters were treated daily for two weeks with either vehicle, fluoxetine, clomipramine, or desipramine (an ineffective drug), before being tested for arginine vasopressin-induced flank marking and grooming. Flank marking was significantly inhibited in animals treated with fluoxetine or clomipramine but unaffected by treatment with desipramine. Grooming behavior was not affected by any treatment. CONCLUSION: These data suggest that arginine vasopressin-induced flank marking may serve as an animal model for screening drugs used in the control of Obsessive Compulsive Disorder.
    Source
    BMC Neurosci. 2001;2:10. Epub 2001 Aug 15.
    DOI
    10.1186/1471-2202-2-10
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/40374
    PubMed ID
    11545675
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2202-2-10
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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