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dc.contributor.authorKeele, Brandon F.
dc.contributor.authorLi, Wenjun
dc.contributor.authorBorducchi, Erica N.
dc.contributor.authorNkolola, Joseph P.
dc.contributor.authorAbbink, Peter
dc.contributor.authorChen, Bing
dc.contributor.authorSeaman, Michael S.
dc.contributor.authorBarouch, Dan H.
dc.date2022-08-11T08:09:48.000
dc.date.accessioned2022-08-23T16:43:51Z
dc.date.available2022-08-23T16:43:51Z
dc.date.issued2017-06-05
dc.date.submitted2017-11-21
dc.identifier.citationNat Commun. 2017 Jun 5;8:15740. doi: 10.1038/ncomms15740. <a href="https://doi.org/10.1038/ncomms15740">Link to article on publisher's site</a>
dc.identifier.issn2041-1723 (Linking)
dc.identifier.doi10.1038/ncomms15740
dc.identifier.pmid28580942
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40383
dc.description.abstractPrevious studies have shown that DNA prime, Ad5 boost vaccines protect against neutralization-sensitive but not neutralization-resistant virus variants within the SIVsmE660 swarm. Here we show that Ad prime, Env protein boost vaccines protect against neutralization-resistant SIVsmE660 variants. We perform two studies in rhesus monkeys with Ad35/Ad26 vectors expressing SIVmac239 Gag/Pol/Env with or without an AS01B-adjuvanted SIVmac32H gp140 protein boost. In a repetitive, low-dose challenge study, we observe robust protection against acquisition of infection by both Ad Alone and Ad/Env vaccines. In a single, high-dose challenge study, only the Ad/Env vaccine affords significant protection against acquisition of infection. Analysis of transmitted/founder (T/F) viruses from this study demonstrates that the Ad/Env vaccine blocks both neutralization-sensitive and neutralization-resistant SIVsmE660 variants in rhesus monkeys with restrictive TRIM5alpha alleles. These data demonstrate that the adjuvanted Env protein boost is critical for protecting against high-dose SIVsmE660 challenge and for blocking neutralization-resistant viruses within the SIVsmE660 swarm.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28580942&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2017, The Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAdaptive immunity
dc.subjectHIV infections
dc.subjectVaccines
dc.subjectImmunity
dc.subjectImmunoprophylaxis and Therapy
dc.subjectVirology
dc.subjectVirus Diseases
dc.subjectViruses
dc.titleAdenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
dc.typeJournal Article
dc.source.journaltitleNature communications
dc.source.volume8
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4196&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3188
dc.identifier.contextkey11106473
refterms.dateFOA2022-08-23T16:43:51Z
html.description.abstract<p>Previous studies have shown that DNA prime, Ad5 boost vaccines protect against neutralization-sensitive but not neutralization-resistant virus variants within the SIVsmE660 swarm. Here we show that Ad prime, Env protein boost vaccines protect against neutralization-resistant SIVsmE660 variants. We perform two studies in rhesus monkeys with Ad35/Ad26 vectors expressing SIVmac239 Gag/Pol/Env with or without an AS01B-adjuvanted SIVmac32H gp140 protein boost. In a repetitive, low-dose challenge study, we observe robust protection against acquisition of infection by both Ad Alone and Ad/Env vaccines. In a single, high-dose challenge study, only the Ad/Env vaccine affords significant protection against acquisition of infection. Analysis of transmitted/founder (T/F) viruses from this study demonstrates that the Ad/Env vaccine blocks both neutralization-sensitive and neutralization-resistant SIVsmE660 variants in rhesus monkeys with restrictive TRIM5alpha alleles. These data demonstrate that the adjuvanted Env protein boost is critical for protecting against high-dose SIVsmE660 challenge and for blocking neutralization-resistant viruses within the SIVsmE660 swarm.</p>
dc.identifier.submissionpathoapubs/3188
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages15740


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