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Alcohol and Cancer: Mechanisms and Therapies

dc.contributor.authorRatna, Anuradha
dc.contributor.authorMandrekar, Pranoti
dc.date2022-08-11T08:09:48.000
dc.date.accessioned2022-08-23T16:44:00Z
dc.date.available2022-08-23T16:44:00Z
dc.date.issued2017-08-14
dc.date.submitted2018-01-08
dc.identifier.citation<p>Biomolecules. 2017 Aug 14;7(3). pii: biom7030061. doi: 10.3390/biom7030061. <a href="https://doi.org/10.3390/biom7030061">Link to article on publisher's site</a></p>
dc.identifier.issn2218-273X (Linking)
dc.identifier.doi10.3390/biom7030061
dc.identifier.pmid28805741
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40416
dc.description.abstractSeveral scientific and clinical studies have shown an association between chronic alcohol consumption and the occurrence of cancer in humans. The mechanism for alcohol-induced carcinogenesis has not been fully understood, although plausible events include genotoxic effects of acetaldehyde, cytochrome P450 2E1 (CYP2E1)-mediated generation of reactive oxygen species, aberrant metabolism of folate and retinoids, increased estrogen, and genetic polymorphisms. Here, we summarize the impact of alcohol drinking on the risk of cancer development and potential underlying molecular mechanisms. The interactions between alcohol abuse, anti-tumor immune response, tumor growth, and metastasis are complex. However, multiple studies have linked the immunosuppressive effects of alcohol with tumor progression and metastasis. The influence of alcohol on the host immune system and the development of possible effective immunotherapy for cancer in alcoholics are also discussed here. The conclusive biological effects of alcohol on tumor progression and malignancy have not been investigated extensively using an animal model that mimics the human disease. This review provides insights into cancer pathogenesis in alcoholics, alcohol and immune interactions in different cancers, and scope and future of targeted immunotherapeutic modalities in patients with alcohol abuse.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28805741&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectalcohol
dc.subjectanimal models
dc.subjectcancer risk
dc.subjectimmunosuppression
dc.subjectimmunotherapy
dc.subjectmetabolism
dc.subjectCancer Biology
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.subjectImmunoprophylaxis and Therapy
dc.subjectNeoplasms
dc.subjectTherapeutics
dc.titleAlcohol and Cancer: Mechanisms and Therapies
dc.typeJournal Article
dc.source.journaltitleBiomolecules
dc.source.volume7
dc.source.issue3
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4231&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3222
dc.identifier.contextkey11333789
refterms.dateFOA2022-08-23T16:44:01Z
html.description.abstract<p>Several scientific and clinical studies have shown an association between chronic alcohol consumption and the occurrence of cancer in humans. The mechanism for alcohol-induced carcinogenesis has not been fully understood, although plausible events include genotoxic effects of acetaldehyde, cytochrome P450 2E1 (CYP2E1)-mediated generation of reactive oxygen species, aberrant metabolism of folate and retinoids, increased estrogen, and genetic polymorphisms. Here, we summarize the impact of alcohol drinking on the risk of cancer development and potential underlying molecular mechanisms. The interactions between alcohol abuse, anti-tumor immune response, tumor growth, and metastasis are complex. However, multiple studies have linked the immunosuppressive effects of alcohol with tumor progression and metastasis. The influence of alcohol on the host immune system and the development of possible effective immunotherapy for cancer in alcoholics are also discussed here. The conclusive biological effects of alcohol on tumor progression and malignancy have not been investigated extensively using an animal model that mimics the human disease. This review provides insights into cancer pathogenesis in alcoholics, alcohol and immune interactions in different cancers, and scope and future of targeted immunotherapeutic modalities in patients with alcohol abuse.</p>
dc.identifier.submissionpathoapubs/3222
dc.contributor.departmentDepartment of Medicine, Division of Gastroenterology


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© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).