UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2017-12-01Keywords
adjuvantsanthelmintics
protective immunity
soil-transmitted helminths
vaccines
Immunoprophylaxis and Therapy
Parasitic Diseases
Parasitology
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Show full item recordAbstract
Soil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and the majority of livestock in the developing world. These gastrointestinal nematodes are the most important parasites on earth with regard to their prevalence in humans and livestock. Current anthelmintic drugs are losing their efficacies due to increasing drug resistance, particularly in STHs of livestock and drug treatment is often followed by rapid reinfection due to failure of the immune system to develop a protective response. Vaccines against STHs offer what drugs cannot accomplish alone. Because such vaccines would have to be produced on such a large scale, and be cost effective, recombinant subunit vaccines that include a minimum number of proteins produced in relatively simple and inexpensive expression systems are required. Here, we summarize all of the previous studies pertaining to recombinant subunit vaccines for STHs of humans and livestock with the goal of both informing the public of just how critical these parasites are, and to help guide future developments. We also discuss several key areas of vaccine development, which we believe to be critical for developing more potent recombinant subunit vaccines with broad-spectrum protection.Source
Parasitology. 2017 Dec;144(14):1845-1870. doi: 10.1017/S003118201700138X. Epub 2017 Aug 3. Link to article on publisher's site
DOI
10.1017/S003118201700138XPermanent Link to this Item
http://hdl.handle.net/20.500.14038/40432PubMed ID
28770689Related Resources
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COPYRIGHT: © Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1017/S003118201700138X
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Except where otherwise noted, this item's license is described as COPYRIGHT: © Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.