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    Towards the reconstruction of central nervous system white matter using neural precursor cells

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    Authors
    Mitome, Masato
    Low, Hoi Pang
    van den Pol, Anthony
    Nunnari, John J.
    Wolf, Merrill K.
    Billings-Gagliardi, Susan
    Schwartz, William J.
    UMass Chan Affiliations
    Department of Cell Biology
    Department of Pathology
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    2001-10-24
    Keywords
    Animals
    Astrocytes
    Axons
    Cells, Cultured
    Central Nervous System
    Corpus Striatum
    Embryo, Mammalian
    Epidermal Growth Factor
    Female
    Injections, Intraventricular
    Lateral Ventricles
    Male
    Mice
    Mice, Inbred C3H
    Mice, Inbred C57BL
    Mice, Neurologic Mutants
    Myelin Basic Proteins
    Myelin Sheath
    Oligodendroglia
    *Stem Cell Transplantation
    Stem Cells
    Life Sciences
    Medicine and Health Sciences
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    Link to Full Text
    https://doi.org/10.1093/brain/124.11.2147
    Abstract
    Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.
    Source

    Brain. 2001 Nov;124(Pt 11):2147-61.

    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/40465
    PubMed ID
    11673317
    Related Resources

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