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dc.contributor.authorMitome, Masato
dc.contributor.authorLow, Hoi Pang
dc.contributor.authorvan den Pol, Anthony
dc.contributor.authorNunnari, John J.
dc.contributor.authorWolf, Merrill K.
dc.contributor.authorBillings-Gagliardi, Susan
dc.contributor.authorSchwartz, William J.
dc.date2022-08-11T08:09:48.000
dc.date.accessioned2022-08-23T16:44:15Z
dc.date.available2022-08-23T16:44:15Z
dc.date.issued2001-10-24
dc.date.submitted2008-04-14
dc.identifier.citation<p>Brain. 2001 Nov;124(Pt 11):2147-61.</p>
dc.identifier.issn0006-8950 (Print)
dc.identifier.pmid11673317
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40465
dc.description.abstractEpidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11673317&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1093/brain/124.11.2147
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectAxons
dc.subjectCells, Cultured
dc.subjectCentral Nervous System
dc.subjectCorpus Striatum
dc.subjectEmbryo, Mammalian
dc.subjectEpidermal Growth Factor
dc.subjectFemale
dc.subjectInjections, Intraventricular
dc.subjectLateral Ventricles
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C3H
dc.subjectMice, Inbred C57BL
dc.subjectMice, Neurologic Mutants
dc.subjectMyelin Basic Proteins
dc.subjectMyelin Sheath
dc.subjectOligodendroglia
dc.subject*Stem Cell Transplantation
dc.subjectStem Cells
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleTowards the reconstruction of central nervous system white matter using neural precursor cells
dc.typeJournal Article
dc.source.journaltitleBrain : a journal of neurology
dc.source.volume124
dc.source.issuePt 11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/327
dc.identifier.contextkey489665
html.description.abstract<p>Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.</p>
dc.identifier.submissionpathoapubs/327
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDepartment of Neurology
dc.source.pages2147-61


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