UMass Chan Affiliations
Department of Molecular, Cell, and Cancer BiologyDocument Type
Journal ArticlePublication Date
2017-10-19Keywords
morpholinoszebrafish
morpholino antisense oligomers
gene knockdown
Genetics and Genomics
Nucleic Acids, Nucleotides, and Nucleosides
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Show full item recordAbstract
The zebrafish (Danio rerio) has emerged as a powerful model to study vertebrate development and disease. Its short generation time makes it amenable to genetic manipulation and analysis, and its small size and high fecundity make it especially well suited for large-scale forward genetic and chemical screens. Fast-developing zebrafish embryos are transparent, facilitating live imaging of a variety of developmental processes in wild-type and mutant animals. ... This brief document provides an updated set of guidelines regarding morpholino use in zebrafish that we anticipate will be of value for experimentalists as well as journal and grant reviewers, and decision makers.Source
PLoS Genet. 2017 Oct 19;13(10):e1007000. doi: 10.1371/journal.pgen.1007000. eCollection 2017 Oct. Link to article on publisher's site
DOI
10.1371/journal.pgen.1007000Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40482PubMed ID
29049395Notes
Full author list omitted for brevity. For the full list of authors, see article.
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Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Distribution License
http://creativecommons.org/publicdomain/zero/1.0/ae974a485f413a2113503eed53cd6c53
10.1371/journal.pgen.1007000
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Except where otherwise noted, this item's license is described as Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.