UMass Chan Affiliations
Department of Medicine, Division of Hematology and OncologyDepartment of Pathology
Department of Medicine, Division of Endocrinology and Metabolism
Document Type
Journal ArticlePublication Date
2017-12-25Keywords
mantle cell lymphomathyroid
Endocrine System Diseases
Endocrinology, Diabetes, and Metabolism
Hemic and Lymphatic Diseases
Neoplasms
Otorhinolaryngologic Diseases
Pathology
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Background: While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that < 1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential. Patient Findings: A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto's thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy. Summary: Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms. Conclusion: Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve.Source
Case Rep Pathol. 2017;2017:6749801. doi: 10.1155/2017/6749801. Epub 2017 Dec 25. Link to article on publisher's site
DOI
10.1155/2017/6749801Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40525PubMed ID
29435379Related Resources
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Copyright © 2017 Uzma Mohammad Siddiqui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1155/2017/6749801
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Except where otherwise noted, this item's license is described as Copyright © 2017 Uzma Mohammad Siddiqui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.