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dc.contributor.authorDale, David C.
dc.contributor.authorBolyard, AudreyAnna
dc.contributor.authorMarrero, Tracy
dc.contributor.authorMakaryan, Vahagn
dc.contributor.authorBonilla, MaryAnn
dc.contributor.authorLink, Daniel C.
dc.contributor.authorNewburger, Peter E.
dc.contributor.authorShimamura, Akiko
dc.contributor.authorBoxer, Laurence A.
dc.contributor.authorSpiekerman, Charles
dc.date2022-08-11T08:09:49.000
dc.date.accessioned2022-08-23T16:44:37Z
dc.date.available2022-08-23T16:44:37Z
dc.date.issued2017-12-07
dc.date.submitted2018-04-04
dc.identifier.citation<p>N Engl J Med. 2017 Dec 7;377(23):2290-2292. doi: 10.1056/NEJMc1709258. <a href="https://doi.org/10.1056/NEJMc1709258">Link to article on publisher's site</a></p>
dc.identifier.issn0028-4793 (Linking)
dc.identifier.doi10.1056/NEJMc1709258
dc.identifier.pmid29211670
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40539
dc.description.abstractCyclic neutropenia is a rare hematologic disease that is characterized by regular oscillations in blood neutrophil counts from normal levels (absolute neutrophil count [ANC], >1.5×109 per liter) to severe neutropenia (ANC, <0.2×109 per liter), usually with a cycle length of about 21 days.When patients with this disorder have neutropenia, they often have fever and mouth ulcers and are at risk for severe infections. Cyclic neutropenia is usually an autosomal dominant disorder caused by mutations in the gene encoding neutrophil elastase (ELANE).
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=29211670&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2017 Massachusetts Medical Society. Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.nejm.org/author-center/permissions.
dc.subjectCyclic Neutropenia
dc.subjectHematology
dc.subjectHemic and Lymphatic Diseases
dc.titleLong-Term Effects of G-CSF Therapy in Cyclic Neutropenia
dc.typeLetter to the Editor
dc.source.journaltitleThe New England journal of medicine
dc.source.volume377
dc.source.issue23
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4355&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3344
dc.legacy.embargo2018-06-07T00:00:00-07:00
dc.identifier.contextkey11902034
refterms.dateFOA2022-08-23T16:44:38Z
html.description.abstract<p>Cyclic neutropenia is a rare hematologic disease that is characterized by regular oscillations in blood neutrophil counts from normal levels (absolute neutrophil count [ANC], >1.5×10<sup>9</sup> per liter) to severe neutropenia (ANC, <0.2×10<sup>9</sup> per liter), usually with a cycle length of about 21 days.When patients with this disorder have neutropenia, they often have fever and mouth ulcers and are at risk for severe infections. Cyclic neutropenia is usually an autosomal dominant disorder caused by mutations in the gene encoding neutrophil elastase (<em>ELANE</em>).</p>
dc.identifier.submissionpathoapubs/3344
dc.contributor.departmentDepartment of Pediatrics, Division of Hematology Oncology
dc.source.pages2290-2292


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