Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity

Koupenova-Zamor, Milka; Ravid, Katya

dc.contributor.author	Koupenova-Zamor, Milka
dc.contributor.author	Ravid, Katya
dc.date	2022-08-11T08:09:49.000
dc.date.accessioned	2022-08-23T16:44:43Z
dc.date.available	2022-08-23T16:44:43Z
dc.date.issued	2018-01-30
dc.date.submitted	2018-04-18
dc.identifier.citation	<p>Front Pharmacol. 2018 Jan 30;9:37. doi: 10.3389/fphar.2018.00037. eCollection 2018. <a href="https://doi.org/10.3389/fphar.2018.00037">Link to article on publisher's site</a></p>
dc.identifier.issn	1663-9812 (Linking)
dc.identifier.doi	10.3389/fphar.2018.00037
dc.identifier.pmid	29441021
dc.identifier.uri	http://hdl.handle.net/20.500.14038/40555
dc.description.abstract	Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic plug, although this activation process becomes problematic in pathological settings of thrombosis. This review briefly outlines the roles and function of currently known platelet purinergic receptors (P1 and P2) in the setting of hemostasis and thrombosis. Additionally, we discuss recent novel studies on purinergic receptor distribution according to heterogeneous platelet size, and the possible implication of this distribution on hemostatic function.
dc.language.iso	en_US
dc.relation	<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=29441021&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights	Copyright © 2018 Koupenova and Ravid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	ADP
dc.subject	ATP
dc.subject	adenosine
dc.subject	platelets
dc.subject	purinergic receptors
dc.subject	Cells
dc.subject	Circulatory and Respiratory Physiology
dc.subject	Hemic and Immune Systems
dc.subject	Medical Pharmacology
dc.subject	Pharmacology
dc.title	Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity
dc.type	Journal Article
dc.source.journaltitle	Frontiers in pharmacology
dc.source.volume	9
dc.identifier.legacyfulltext	https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4371&context=oapubs&unstamped=1
dc.identifier.legacycoverpage	https://escholarship.umassmed.edu/oapubs/3360
dc.identifier.contextkey	11980773
refterms.dateFOA	2022-08-23T16:44:43Z
html.description.abstract	<p>Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic plug, although this activation process becomes problematic in pathological settings of thrombosis. This review briefly outlines the roles and function of currently known platelet purinergic receptors (P1 and P2) in the setting of hemostasis and thrombosis. Additionally, we discuss recent novel studies on purinergic receptor distribution according to heterogeneous platelet size, and the possible implication of this distribution on hemostatic function.</p>
dc.identifier.submissionpath	oapubs/3360
dc.contributor.department	Department of Medicine, Division of Cardiovascular Medicine
dc.source.pages	37

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Copyright © 2018 Koupenova and Ravid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Except where otherwise noted, this item's license is described as Copyright © 2018 Koupenova and Ravid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.