Excitatory motor neurons are local oscillators for backward locomotion
Guan, Sihui Asuka
Fouad, Anthony D.
Qi, Yingchuan Billy
Alkema, Mark J.
UMass Chan AffiliationsGraduate School of Biomedical Sciences, Neuroscience Program
Department of Neurobiology
Central Pattern Generator (CPG)
Neuroscience and Neurobiology
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AbstractCell- or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging, we show: (1) forward and backward locomotion is driven by different oscillators; (2) the cholinergic and excitatory A-class motor neurons exhibit intrinsic and oscillatory activity that is sufficient to drive backward locomotion in the absence of premotor interneurons; (3) the UNC-2 P/Q/N high-voltage-activated calcium current underlies A motor neuron's oscillation; (4) descending premotor interneurons AVA, via an evolutionarily conserved, mixed gap junction and chemical synapse configuration, exert state-dependent inhibition and potentiation of A motor neuron's intrinsic activity to regulate backward locomotion. Thus, motor neurons themselves derive rhythms, which are dually regulated by the descending interneurons to control the reversal motor state. These and previous findings exemplify compression: essential circuit properties are conserved but executed by fewer numbers and layers of neurons in a small locomotor network.
Elife. 2018 Jan 23;7. pii: 29915. doi: 10.7554/eLife.29915. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/40559
RightsCopyright Gao et al. This article is distributed under the terms of the Creative Commons License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright Gao et al. This article is distributed under the terms of the Creative Commons License, which permits unrestricted use and redistribution provided that the original author and source are credited.