Donated chemical probes for open science
Document Type
Journal ArticlePublication Date
2018-04-20Keywords
Chemical probesOpen Science
Target validation
biochemistry
chemical biology
Amino Acids, Peptides, and Proteins
Biochemistry
Chemical and Pharmacologic Phenomena
Chemicals and Drugs
Medicinal-Pharmaceutical Chemistry
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Show full item recordAbstract
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.Source
Elife. 2018 Apr 20;7. pii: 34311. doi: 10.7554/eLife.34311. Link to article on publisher's site
DOI
10.7554/eLife.34311Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40639PubMed ID
29676732Notes
Full author list omitted for brevity. For the full list of authors, see article.
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Copyright 2018 Muller et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.Distribution License
http://creativecommons.org/licenses/by/4.0/Scopus Count
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Except where otherwise noted, this item's license is described as Copyright 2018 Muller et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
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