IL-15 supports the generation of protective lung-resident memory CD4 T cells
AuthorsStrutt, T. M.
Finn, C. M.
Hwang, J. H.
Swain, Susan L.
McKinstry, K. K.
UMass Chan AffiliationsDepartment of Pathology
Document TypeJournal Article
KeywordsImmunology of Infectious Disease
Pathological Conditions, Signs and Symptoms
Respiratory Tract Diseases
MetadataShow full item record
AbstractTissue-resident memory T cells (TRM) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinct pathways that lead to the generation of CD4 TRM in the lungs following influenza infection. The TRM are transcriptionally distinct from conventional memory CD4 T cells and share a gene signature with CD8 TRM. The CD4 TRM are superior cytokine producers compared with conventional memory cells, can protect otherwise naive mice against a lethal influenza challenge, and display functional specialization by inducing enhanced inflammatory responses from dendritic cells compared with conventional memory cells. Finally, we demonstrate than an interleukin (IL)-2-dependent and a novel IL-2-independent but IL-15-dependent pathway support the generation of cohorts of lung TRM.
Mucosal Immunol. 2018 May;11(3):668-680. doi: 10.1038/mi.2017.101. Epub 2017 Nov 29. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/40666