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dc.contributor.authorGuilherme, Adilson L.
dc.contributor.authorPedersen, David J.
dc.contributor.authorHenriques, Felipe
dc.contributor.authorBedard, Alexander H.
dc.contributor.authorHenchey, Elizabeth
dc.contributor.authorKelly, Mark
dc.contributor.authorMorgan, Donald A.
dc.contributor.authorRahmouni, Kamal
dc.contributor.authorCzech, Michael P.
dc.date2022-08-11T08:09:50.000
dc.date.accessioned2022-08-23T16:45:36Z
dc.date.available2022-08-23T16:45:36Z
dc.date.issued2018-06-27
dc.date.submitted2018-08-16
dc.identifier.citation<p>Mol Metab. 2018 Jun 27. pii: S2212-8778(18)30518-0. doi: 10.1016/j.molmet.2018.06.014. [Epub ahead of print]. <a href="https://doi.org/10.1016/j.molmet.2018.06.014">Link to article on publisher's site</a></p>
dc.identifier.issn2212-8778 (Linking)
dc.identifier.doi10.1016/j.molmet.2018.06.014
dc.identifier.pmid30005879
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40714
dc.description.abstractOBJECTIVE: Crosstalk between adipocytes and local neurons may be an important regulatory mechanism to control energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) expands sympathetic neurons within white adipose tissue (WAT) and stimulates the appearance of "beige" adipocytes. Here we tested whether WAT DNL activity can also influence neuronal regulation and thermogenesis in brown adipose tissue (BAT). METHODS AND RESULTS: Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. This increased sympathetic innervation could be observed at both 22 degrees C and 30 degrees C, indicating it is not a response to heat loss but rather adipocyte signaling. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed. CONCLUSION: These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30005879&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright 2018 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdipocytes
dc.subjectBrown adipose tissue
dc.subjectLipogenesis
dc.subjectSNS outflow
dc.subjectSensory nerve
dc.subjectSympathetic nerve
dc.subjectThermogenesis
dc.subjectBiochemical Phenomena, Metabolism, and Nutrition
dc.subjectCellular and Molecular Physiology
dc.subjectDevelopmental Biology
dc.subjectDevelopmental Neuroscience
dc.subjectEndocrinology
dc.subjectMolecular Biology
dc.subjectNervous System
dc.titleNeuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis
dc.typeJournal Article
dc.source.journaltitleMolecular metabolism
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4530&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3518
dc.identifier.contextkey12668444
refterms.dateFOA2022-08-23T16:45:36Z
html.description.abstract<p>OBJECTIVE: Crosstalk between adipocytes and local neurons may be an important regulatory mechanism to control energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) expands sympathetic neurons within white adipose tissue (WAT) and stimulates the appearance of "beige" adipocytes. Here we tested whether WAT DNL activity can also influence neuronal regulation and thermogenesis in brown adipose tissue (BAT).</p> <p>METHODS AND RESULTS: Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. This increased sympathetic innervation could be observed at both 22 degrees C and 30 degrees C, indicating it is not a response to heat loss but rather adipocyte signaling. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed.</p> <p>CONCLUSION: These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.</p>
dc.identifier.submissionpathoapubs/3518
dc.contributor.departmentProgram in Molecular Medicine


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Copyright 2018 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as Copyright 2018 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).