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dc.contributor.authorTopor, Lisa Swartz
dc.contributor.authorBowerman, Kimberly
dc.contributor.authorMachan, Jason T.
dc.contributor.authorGilbert, Courtney L.
dc.contributor.authorKangarloo, Tairmae
dc.contributor.authorShaw, Natalie D.
dc.date2022-08-11T08:09:50.000
dc.date.accessioned2022-08-23T16:45:37Z
dc.date.available2022-08-23T16:45:37Z
dc.date.issued2018-06-27
dc.date.submitted2018-08-16
dc.identifier.citation<p>PLoS One. 2018 Jun 27;13(6):e0199019. doi: 10.1371/journal.pone.0199019. eCollection 2018. <a href="https://doi.org/10.1371/journal.pone.0199019">Link to article on publisher's site</a></p>
dc.identifier.issn1932-6203 (Linking)
dc.identifier.doi10.1371/journal.pone.0199019
dc.identifier.pmid29949619
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40717
dc.description.abstractOBJECTIVE: Recent studies in the US and abroad suggest that boys are undergoing puberty at a younger age. It is unknown if this secular trend extends to boys with central precocious puberty (CPP), who sit at the extreme end of the pubertal spectrum, and if neuroimaging should remain a standard diagnostic tool. STUDY DESIGN: Retrospective chart review of all boys with CPP seen by Endocrinology at a US pediatric hospital from 2001-2010. RESULTS: Fifty boys had pubertal onset at an average age of 7.31 years (95CI 6.83-7.89), though many did not present until nearly one year thereafter, by which time 30% were mid-to-late pubertal. Boys were predominantly non-Hispanic White and 64% were overweight/obese. The majority (64%) of boys had neurogenic CPP (CNS-CPP) with neurofibromatosis type I being the most common diagnosis. Diagnosis of CPP led to discovery of a neurogenic lesion in only 3 of 32 (9%) CNS-CPP cases. The remaining boys, with idiopathic CPP (36%), were indistinguishable from those with CNS-CPP aside from four boys who endorsed a family history of PP (22% vs. 0% among CNS-CPP cases). Importantly, there was no change in the incidence of male CPP after accounting for the increase in clinic volume during this time period. CONCLUSION: In this contemporary Boston-based cohort of 50 boys with CPP, most cases were neurogenic, consistent with older literature. Several idiopathic cases had a family history of PP but were otherwise indistinguishable from CNS-CPP cases. Thus, neuroimaging remains a critical diagnostic tool. We find no evidence for an increase in the prevalence of male CPP.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=29949619&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectPuberty
dc.subjectCancer detection and diagnosis
dc.subjectPediatric endocrinology
dc.subjectPediatrics
dc.subjectNeuroimaging
dc.subjectDiagnostic medicine
dc.subjectBrain damage
dc.subjectEndocrinology
dc.subjectCongenital, Hereditary, and Neonatal Diseases and Abnormalities
dc.subjectEndocrine System Diseases
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectPediatrics
dc.subjectReproductive and Urinary Physiology
dc.titleCentral precocious puberty in Boston boys: A 10-year single center experience
dc.typeJournal Article
dc.source.journaltitlePloS one
dc.source.volume13
dc.source.issue6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4532&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3520
dc.identifier.contextkey12668446
refterms.dateFOA2022-08-23T16:45:37Z
html.description.abstract<p>OBJECTIVE: Recent studies in the US and abroad suggest that boys are undergoing puberty at a younger age. It is unknown if this secular trend extends to boys with central precocious puberty (CPP), who sit at the extreme end of the pubertal spectrum, and if neuroimaging should remain a standard diagnostic tool.</p> <p>STUDY DESIGN: Retrospective chart review of all boys with CPP seen by Endocrinology at a US pediatric hospital from 2001-2010.</p> <p>RESULTS: Fifty boys had pubertal onset at an average age of 7.31 years (95CI 6.83-7.89), though many did not present until nearly one year thereafter, by which time 30% were mid-to-late pubertal. Boys were predominantly non-Hispanic White and 64% were overweight/obese. The majority (64%) of boys had neurogenic CPP (CNS-CPP) with neurofibromatosis type I being the most common diagnosis. Diagnosis of CPP led to discovery of a neurogenic lesion in only 3 of 32 (9%) CNS-CPP cases. The remaining boys, with idiopathic CPP (36%), were indistinguishable from those with CNS-CPP aside from four boys who endorsed a family history of PP (22% vs. 0% among CNS-CPP cases). Importantly, there was no change in the incidence of male CPP after accounting for the increase in clinic volume during this time period.</p> <p>CONCLUSION: In this contemporary Boston-based cohort of 50 boys with CPP, most cases were neurogenic, consistent with older literature. Several idiopathic cases had a family history of PP but were otherwise indistinguishable from CNS-CPP cases. Thus, neuroimaging remains a critical diagnostic tool. We find no evidence for an increase in the prevalence of male CPP.</p>
dc.identifier.submissionpathoapubs/3520
dc.contributor.departmentDepartment of Medicine
dc.source.pagese0199019


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Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.  The work is made available under the Creative Commons CC0 public domain dedication.
Except where otherwise noted, this item's license is described as Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.