One Group's Historical Reflections on DNA Vaccine Development
UMass Chan Affiliations
Department of MedicineDocument Type
Journal ArticlePublication Date
2018-09-01Keywords
DNA vaccinesantibody
cytotoxic T cells
heterologous prime-boost
Amino Acids, Peptides, and Proteins
Genetics and Genomics
Immunoprophylaxis and Therapy
Therapeutics
Metadata
Show full item recordAbstract
DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.Source
Hum Gene Ther. 2018 Sep;29(9):966-970. doi: 10.1089/hum.2018.066. Epub 2018 Aug 21. Link to article on publisher's site
DOI
10.1089/hum.2018.066Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40765PubMed ID
30129778Related Resources
Rights
Copyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Distribution License
http://creativecommons.org/licenses/by/4.0/Scopus Count
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Except where otherwise noted, this item's license is described as Copyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.