One Group's Historical Reflections on DNA Vaccine Development
dc.contributor.author | Fynan, Ellen F. | |
dc.contributor.author | Lu, Shan | |
dc.contributor.author | Robinson, Harriet L. | |
dc.date | 2022-08-11T08:09:51.000 | |
dc.date.accessioned | 2022-08-23T16:45:51Z | |
dc.date.available | 2022-08-23T16:45:51Z | |
dc.date.issued | 2018-09-01 | |
dc.date.submitted | 2018-10-05 | |
dc.identifier.citation | <p>Hum Gene Ther. 2018 Sep;29(9):966-970. doi: 10.1089/hum.2018.066. Epub 2018 Aug 21. <a href="https://doi.org/10.1089/hum.2018.066">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 1043-0342 (Linking) | |
dc.identifier.doi | 10.1089/hum.2018.066 | |
dc.identifier.pmid | 30129778 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/40765 | |
dc.description.abstract | DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30129778&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.rights | Copyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | DNA vaccines | |
dc.subject | antibody | |
dc.subject | cytotoxic T cells | |
dc.subject | heterologous prime-boost | |
dc.subject | Amino Acids, Peptides, and Proteins | |
dc.subject | Genetics and Genomics | |
dc.subject | Immunoprophylaxis and Therapy | |
dc.subject | Therapeutics | |
dc.title | One Group's Historical Reflections on DNA Vaccine Development | |
dc.type | Journal Article | |
dc.source.journaltitle | Human gene therapy | |
dc.source.volume | 29 | |
dc.source.issue | 9 | |
dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4581&context=oapubs&unstamped=1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/3569 | |
dc.identifier.contextkey | 13027744 | |
refterms.dateFOA | 2022-08-23T16:45:51Z | |
html.description.abstract | <p>DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.</p> | |
dc.identifier.submissionpath | oapubs/3569 | |
dc.contributor.department | Department of Medicine | |
dc.source.pages | 966-970 |