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dc.contributor.authorFynan, Ellen F.
dc.contributor.authorLu, Shan
dc.contributor.authorRobinson, Harriet L.
dc.date2022-08-11T08:09:51.000
dc.date.accessioned2022-08-23T16:45:51Z
dc.date.available2022-08-23T16:45:51Z
dc.date.issued2018-09-01
dc.date.submitted2018-10-05
dc.identifier.citation<p>Hum Gene Ther. 2018 Sep;29(9):966-970. doi: 10.1089/hum.2018.066. Epub 2018 Aug 21. <a href="https://doi.org/10.1089/hum.2018.066">Link to article on publisher's site</a></p>
dc.identifier.issn1043-0342 (Linking)
dc.identifier.doi10.1089/hum.2018.066
dc.identifier.pmid30129778
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40765
dc.description.abstractDNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30129778&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDNA vaccines
dc.subjectantibody
dc.subjectcytotoxic T cells
dc.subjectheterologous prime-boost
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectGenetics and Genomics
dc.subjectImmunoprophylaxis and Therapy
dc.subjectTherapeutics
dc.titleOne Group's Historical Reflections on DNA Vaccine Development
dc.typeJournal Article
dc.source.journaltitleHuman gene therapy
dc.source.volume29
dc.source.issue9
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4581&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3569
dc.identifier.contextkey13027744
refterms.dateFOA2022-08-23T16:45:51Z
html.description.abstract<p>DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.</p>
dc.identifier.submissionpathoapubs/3569
dc.contributor.departmentDepartment of Medicine
dc.source.pages966-970


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Copyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.