Heat Stroke as a Cause of Liver Failure and Evaluation of Liver Transplant
Authors
Martins, Paulo N.A.Bruggenwirth, Isabel M. A.
McDaid, James
Hertl, Martin
Kawai, Tatsuo
Elias, Nahel
Chung, Raymond T.
Markmann, James F.
UMass Chan Affiliations
Department of Surgery, Division of Organ TransplantationDocument Type
Journal ArticlePublication Date
2018-08-17Keywords
Acute liver failureEmergency liver transplant
Elevated body temperature
Exertional heat stroke
Heat shock
Heat stroke-associated liver failure
Digestive System Diseases
Surgery
Surgical Procedures, Operative
Metadata
Show full item recordAbstract
Heat stroke is a multiple organ dysfunction syndrome of poorly understood pathogenesis. Exertional heat stroke with acute liver failure is a rarely reported condition. Liver transplant has been recommended as treatment in cases of severe liver dysfunction; however, there are only 5 described cases of long-term survival after this procedure in patients with heat stroke. Here, we present 2 cases of young athletes who developed heat stroke. Both patients developed acute liver failure and were listed for liver transplant. Liver function tests of one patient improved, and he was discharged on postoperative day 13. The other patient showed no signs of improvement and liver biopsy showed massive necrosis. The patient underwent combined kidney-liver transplant and was discharged on postoperative day 17. After a follow-up of longer than 6 years, both patients are doing well with normal liver function and no neurologic sequelae. We also reviewed all published cases of hepatic failure associated with heat stroke and found 9 published cases of liver transplant for heat stroke in the English literature. Conservative management appears to be justified in heat stroke-associated liver failure, even in the presence of accepted criteria for emergency liver transplant.Source
Exp Clin Transplant. 2018 Aug 17. doi: 10.6002/ect.2018.0003. Link to article on publisher's site
DOI
10.6002/ect.2018.0003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40779PubMed ID
30119616Related Resources
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Copyright © Başkent University 2018ae974a485f413a2113503eed53cd6c53
10.6002/ect.2018.0003
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