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dc.contributor.authorDolgin, Natasha H.
dc.contributor.authorSmith, Andrew J.
dc.contributor.authorHarrington, Samantha G.
dc.contributor.authorMovahedi, Babak
dc.contributor.authorMartins, Paulo N.A.
dc.contributor.authorBozorgzadeh, Adel
dc.date2022-08-11T08:09:51.000
dc.date.accessioned2022-08-23T16:46:17Z
dc.date.available2022-08-23T16:46:17Z
dc.date.issued2018-10-05
dc.date.submitted2018-12-12
dc.identifier.citation<p>Exp Clin Transplant. 2018 Oct 5. doi: 10.6002/ect.2018.0018. [Epub ahead of print] <a href="https://doi.org/10.6002/ect.2018.0018">Link to article on publisher's site</a></p>
dc.identifier.issn1304-0855 (Linking)
dc.identifier.doi10.6002/ect.2018.0018
dc.identifier.pmid30295589
dc.identifier.urihttp://hdl.handle.net/20.500.14038/40850
dc.description.abstractOBJECTIVES: A growing body of evidence shows that frailty and functional performance predict liver transplant outcomes. The Organ Procurement and Transplant Network uses the Karnofsky Performance Status scale to adjust for transplant center case mix in assessing quality measures. This study explores the strength of the relationship between Karnofsky Performance Status scores and objective measures of frailty. MATERIALS AND METHODS: This observational study includes 136 adult, first-time liver transplant recipients at UMass Memorial (2006-2015) who had 2 abdominal computed tomography scans available (at < /= 90 days pretransplant and > /= 7 days before that). We analyzed the relationship between Karnofsky Performance Status and muscle wasting using absolute and change in psoas muscle size and quality pretransplant. RESULTS: The mean age was 55 years, mean Model for End-Stage Liver Disease was 22, and 34% of patients were women. In the study group, 50% of patients had sarcopenia pretransplant and 71.3% demonstrated declined lean psoas area at an average rate of 11% per month. Patients who experienced muscle wasting at a rate of > /= 1% per month had 2.83 times the risk (95% confidence interval, 1.18-6.80) of being severely impaired/disabled pretransplant. The risk increased by 2.32-fold (95% confidence interval, 1.44-3.75) for every standard deviation decrease in pretransplant lean psoas area. CONCLUSIONS: Provider-assessed physical health status moderately correlates with objective measures of frailty.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30295589&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © Başkent University 2018
dc.subjectBiostatistics
dc.subjectFrailty
dc.subjectHepatology
dc.subjectKarnofsky Performance Status
dc.subjectUnited Network for Organ Sharing
dc.subjectDigestive System Diseases
dc.subjectHepatology
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectSurgery
dc.subjectSurgical Procedures, Operative
dc.titleAssociation Between Sarcopenia and Functional Status in Liver Transplant Patients
dc.typeJournal Article
dc.source.journaltitleExperimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4668&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3656
dc.identifier.contextkey13473115
refterms.dateFOA2022-08-23T16:46:17Z
html.description.abstract<p>OBJECTIVES: A growing body of evidence shows that frailty and functional performance predict liver transplant outcomes. The Organ Procurement and Transplant Network uses the Karnofsky Performance Status scale to adjust for transplant center case mix in assessing quality measures. This study explores the strength of the relationship between Karnofsky Performance Status scores and objective measures of frailty.</p> <p>MATERIALS AND METHODS: This observational study includes 136 adult, first-time liver transplant recipients at UMass Memorial (2006-2015) who had 2 abdominal computed tomography scans available (at < /= 90 days pretransplant and > /= 7 days before that). We analyzed the relationship between Karnofsky Performance Status and muscle wasting using absolute and change in psoas muscle size and quality pretransplant.</p> <p>RESULTS: The mean age was 55 years, mean Model for End-Stage Liver Disease was 22, and 34% of patients were women. In the study group, 50% of patients had sarcopenia pretransplant and 71.3% demonstrated declined lean psoas area at an average rate of 11% per month. Patients who experienced muscle wasting at a rate of > /= 1% per month had 2.83 times the risk (95% confidence interval, 1.18-6.80) of being severely impaired/disabled pretransplant. The risk increased by 2.32-fold (95% confidence interval, 1.44-3.75) for every standard deviation decrease in pretransplant lean psoas area.</p> <p>CONCLUSIONS: Provider-assessed physical health status moderately correlates with objective measures of frailty.</p>
dc.identifier.submissionpathoapubs/3656
dc.contributor.departmentGraduate School of Biomedical Sciences, Clinical and Population Health Research Program
dc.contributor.departmentDepartment of Radiology
dc.contributor.departmentDepartment of Surgery, Center for Outcomes Research
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Surgery, Division of Organ Transplantation


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