No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications
dc.contributor.author | Quitadamo, Briana | |
dc.contributor.author | Peters, Paul J. | |
dc.contributor.author | Koch, Matthew | |
dc.contributor.author | Luzuriaga, Katherine | |
dc.contributor.author | Cheng-Mayer, Cecilia | |
dc.contributor.author | Clapham, Paul R. | |
dc.contributor.author | Gonzalez-Perez, Maria Paz | |
dc.date | 2022-08-11T08:09:52.000 | |
dc.date.accessioned | 2022-08-23T16:46:53Z | |
dc.date.available | 2022-08-23T16:46:53Z | |
dc.date.issued | 2019-02-01 | |
dc.date.submitted | 2019-05-06 | |
dc.identifier.citation | <p>Arch Virol. 2019 Feb;164(2):473-482. doi: 10.1007/s00705-018-4094-1. Epub 2018 Nov 10. <a href="https://doi.org/10.1007/s00705-018-4094-1">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 0304-8608 (Linking) | |
dc.identifier.doi | 10.1007/s00705-018-4094-1 | |
dc.identifier.pmid | 30415390 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/40968 | |
dc.description.abstract | Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection via CD4, which is in low abundance. In contrast, mac-tropic SIV is associated with CD4-independent infection via direct CCR5 binding. Recently, mac-tropic simian-human immunodeficiency virus (SHIV) from macaque brain was also reported to infect cells via CCR5 without CD4. Since SHIV envelope proteins (Envs) are derived from HIV-1, we tested more than 100 HIV-1 clade B Envs for infection of CD4-negative, CCR5(+) Cf2Th/CCR5 cells. However, no infection was detected. Our data suggest that there are differences in the evolution of mac-tropism in SIV and SHIV compared to HIV-1 clade B due to enhanced interactions with CCR5 and CD4, respectively. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30415390&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.rights | © The Author(s) 2018. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Amino Acids, Peptides, and Proteins | |
dc.subject | Animal Experimentation and Research | |
dc.subject | Hemic and Immune Systems | |
dc.subject | Immunology of Infectious Disease | |
dc.subject | Nervous System | |
dc.subject | Virology | |
dc.subject | Viruses | |
dc.title | No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications | |
dc.type | Journal Article | |
dc.source.journaltitle | Archives of virology | |
dc.source.volume | 164 | |
dc.source.issue | 2 | |
dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4781&context=oapubs&unstamped=1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/3767 | |
dc.identifier.contextkey | 14438105 | |
refterms.dateFOA | 2022-08-23T16:46:53Z | |
html.description.abstract | <p>Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection via CD4, which is in low abundance. In contrast, mac-tropic SIV is associated with CD4-independent infection via direct CCR5 binding. Recently, mac-tropic simian-human immunodeficiency virus (SHIV) from macaque brain was also reported to infect cells via CCR5 without CD4. Since SHIV envelope proteins (Envs) are derived from HIV-1, we tested more than 100 HIV-1 clade B Envs for infection of CD4-negative, CCR5(+) Cf2Th/CCR5 cells. However, no infection was detected. Our data suggest that there are differences in the evolution of mac-tropism in SIV and SHIV compared to HIV-1 clade B due to enhanced interactions with CCR5 and CD4, respectively.</p> | |
dc.identifier.submissionpath | oapubs/3767 | |
dc.contributor.department | Program in Molecular Medicine | |
dc.source.pages | 473-482 |