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Authors
Lee, YongchanHamann, Jens C.
Pellegrino, Mark
Durgan, Joanne
Domart, Marie-Charlotte
Collinson, Lucy M.
Haynes, Cole M.
Florey, Oliver
Overholtzer, Michael
UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyDocument Type
Journal ArticlePublication Date
2019-03-19Keywords
cell adhesioncell cannibalism
engulfment
entosis
entotic cell death
gonad
linker cell death
lobe
scission
uropod
Cell Biology
Cells
Developmental Biology
Embryonic Structures
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Show full item recordAbstract
Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to clear the male-specific linker cell in C. elegans. The linker cell leads migration to shape the gonad and is removed to facilitate fusion of the gonad to the cloaca. We find that the linker cell is cleared in a manner involving cell-cell adhesions and cell-autonomous control of uptake through linker cell actin. Linker cell entosis generates a lobe structure that is deposited at the site of gonad-to-cloaca fusion and is removed during mating. Inhibition of lobe scission inhibits linker cell death, demonstrating that the linker cell invades its host while alive. Our findings demonstrate a developmental function for entosis: to eliminate a migrating cell and facilitate gonad-to-cloaca fusion, which is required for fertility.Source
Cell Rep. 2019 Mar 19;26(12):3212-3220.e4. doi: 10.1016/j.celrep.2019.02.073. Link to article on publisher's site
DOI
10.1016/j.celrep.2019.02.073Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40990PubMed ID
30893595Related Resources
Rights
Copyright 2019 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2019.02.073
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Except where otherwise noted, this item's license is described as Copyright 2019 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).