The role of platelets in mediating a response to human influenza infection
UMass Chan Affiliations
Department of Medicine, Division of Infectious Disease and ImmunologyDepartment of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2019-04-16Keywords
influenzainfluenza infection
platelets
myocardial infarction
Cardiology
Cardiovascular Diseases
Cells
Fluids and Secretions
Hemic and Immune Systems
ImmunityImmunology of Infectious DiseaseImmunopathologyInfectious DiseaseInfluenza HumansRespiratory Tract DiseasesVirus Diseases
Metadata
Show full item recordAbstract
Influenza infection increases the incidence of myocardial infarction but the reason is unknown. Platelets mediate vascular occlusion through thrombotic functions but are also recognized to have immunomodulatory activity. To determine if platelet processes are activated during influenza infection, we collected blood from 18 patients with acute influenza infection. Microscopy reveals activated platelets, many containing viral particles and extracellular-DNA associated with platelets. To understand the mechanism, we isolate human platelets and treat them with influenza A virus. Viral-engulfment leads to C3 release from platelets as a function of TLR7 and C3 leads to neutrophil-DNA release and aggregation. TLR7 specificity is confirmed in murine models lacking the receptor, and platelet depletion models support platelet-mediated C3 and neutrophil-DNA release post-influenza infection. These findings demonstrate that the initial intrinsic defense against influenza is mediated by platelet-neutrophil cross-communication that tightly regulates host immune and complement responses but can also lead to thrombotic vascular occlusion.Source
Nat Commun. 2019 Apr 16;10(1):1780. doi: 10.1038/s41467-019-09607-x. Link to article on publisher's site
DOI
10.1038/s41467-019-09607-xPermanent Link to this Item
http://hdl.handle.net/20.500.14038/41043PubMed ID
30992428Related Resources
Rights
Copyright © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Distribution License
http://creativecommons.org/licenses/by/4.0/Scopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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