Show simple item record

dc.contributor.authorDavis, Julie E.
dc.contributor.authorHarkey, Matthew S.
dc.contributor.authorWard, Robert J.
dc.contributor.authorMacKay, James W.
dc.contributor.authorLu, Bing
dc.contributor.authorPrice, Lori Lyn
dc.contributor.authorEaton, Charles B.
dc.contributor.authorLo, Grace H.
dc.contributor.authorBarbe, Mary F.
dc.contributor.authorMcAlindon, Timothy E.
dc.contributor.authorDriban, Jeffrey B.
dc.date2022-08-11T08:09:53.000
dc.date.accessioned2022-08-23T16:47:26Z
dc.date.available2022-08-23T16:47:26Z
dc.date.issued2019-06-29
dc.date.submitted2019-07-18
dc.identifier.citation<p>BMC Musculoskelet Disord. 2019 Jun 29;20(1):308. doi: 10.1186/s12891-019-2685-y. <a href="https://doi.org/10.1186/s12891-019-2685-y">Link to article on publisher's site</a></p>
dc.identifier.issn1471-2474 (Linking)
dc.identifier.doi10.1186/s12891-019-2685-y
dc.identifier.pmid31253142
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41078
dc.description.abstractBACKGROUND: To determine if adults with incident accelerated knee osteoarthritis (KOA) are more likely to have degenerative knee ligaments or tendons compared to individuals with typical or no KOA. METHODS: We identified 3 sex-matched groups among Osteoarthritis Initiative participants who had a knee without radiographic KOA at baseline (Kellgren-Lawrence [KL] < 2): 1) accelerated KOA: at least 1 knee had KL grade > /= 3 in < /=48 months, 2) typical KOA: at least 1 knee increased in radiographic scoring within 48 months, 3) no KOA: both knees had the same KL grade at baseline and 48 months. We evaluated knee magnetic resonance images up to 2 years before and after a visit when the accelerated or typical KOA criteria were met (index visit). Radiologists reported degenerative signal changes for cruciate and collateral ligaments, and extensor mechanism and proximal gastrocnemius tendons. We used generalized linear mixed models with 2 independent variables: group and time. RESULTS: Starting at least 2 years before onset, adults with accelerated KOA were twice as likely to have degenerative cruciate ligaments than no KOA (odds ratio = 2.10, 95% CI = 1.18, 3.74). A weaker association (not statistically significant) was detected for adults with accelerated versus typical KOA (OR = 1.72, 95%CI = 0.99, 3.02). Regardless of time, adults with accelerated (odds ratio = 2.13) or typical KOA (odds ratio = 2.16) were twice as likely to have a degenerative extensor mechanism than no KOA. No other structural features were statistically significant. CONCLUSIONS: Degenerative cruciate ligaments or extensor mechanism antedate radiographic onset of accelerated KOA. Hence, knee instability may precede accelerated KOA, which might help identify patients at high-risk for accelerated KOA and novel prevention strategies.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=31253142&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© The Author(s). 2019 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.subjectEpidemiology
dc.subjectKnee
dc.subjectLigaments
dc.subjectOsteoarthritis
dc.subjectTendons
dc.subjectEpidemiology
dc.subjectMusculoskeletal Diseases
dc.subjectMusculoskeletal System
dc.subjectRadiology
dc.subjectRheumatology
dc.titleAccelerated knee osteoarthritis is associated with pre-radiographic degeneration of the extensor mechanism and cruciate ligaments: data from the Osteoarthritis Initiative
dc.typeArticle
dc.source.journaltitleBMC musculoskeletal disorders
dc.source.volume20
dc.source.issue1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4884&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3869
dc.identifier.contextkey14951159
refterms.dateFOA2022-08-23T16:47:26Z
html.description.abstract<p>BACKGROUND: To determine if adults with incident accelerated knee osteoarthritis (KOA) are more likely to have degenerative knee ligaments or tendons compared to individuals with typical or no KOA.</p> <p>METHODS: We identified 3 sex-matched groups among Osteoarthritis Initiative participants who had a knee without radiographic KOA at baseline (Kellgren-Lawrence [KL] < 2): 1) accelerated KOA: at least 1 knee had KL grade > /= 3 in < /=48 months, 2) typical KOA: at least 1 knee increased in radiographic scoring within 48 months, 3) no KOA: both knees had the same KL grade at baseline and 48 months. We evaluated knee magnetic resonance images up to 2 years before and after a visit when the accelerated or typical KOA criteria were met (index visit). Radiologists reported degenerative signal changes for cruciate and collateral ligaments, and extensor mechanism and proximal gastrocnemius tendons. We used generalized linear mixed models with 2 independent variables: group and time.</p> <p>RESULTS: Starting at least 2 years before onset, adults with accelerated KOA were twice as likely to have degenerative cruciate ligaments than no KOA (odds ratio = 2.10, 95% CI = 1.18, 3.74). A weaker association (not statistically significant) was detected for adults with accelerated versus typical KOA (OR = 1.72, 95%CI = 0.99, 3.02). Regardless of time, adults with accelerated (odds ratio = 2.13) or typical KOA (odds ratio = 2.16) were twice as likely to have a degenerative extensor mechanism than no KOA. No other structural features were statistically significant.</p> <p>CONCLUSIONS: Degenerative cruciate ligaments or extensor mechanism antedate radiographic onset of accelerated KOA. Hence, knee instability may precede accelerated KOA, which might help identify patients at high-risk for accelerated KOA and novel prevention strategies.</p>
dc.identifier.submissionpathoapubs/3869
dc.contributor.departmentDepartment of Population and Quantitative Health Sciences
dc.source.pages308


Files in this item

Thumbnail
Name:
s12891_019_2685_y.pdf
Size:
465.8Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record