Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
AuthorsKumar, Nathella Pavan
Fukutani, Kiyoshi F.
Shruthi, Basavaradhya S.
Silveira-Mattos, Paulo S.
Rocha, Michael S.
Andrade, Bruno B.
UMass Chan AffiliationsDepartment of Medicine, Division of Pulmonary, Allergy And Critical Care Medicine
Allergy and Immunology
Bacterial Infections and Mycoses
Endocrine System Diseases
Immunology of Infectious Disease
Nutritional and Metabolic Diseases
Pathological Conditions, Signs and Symptoms
MetadataShow full item record
AbstractDiabetes mellitus (DM) increases risk for pulmonary tuberculosis (TB) and adverse treatment outcomes. Systemic hyper-inflammation is characteristic in people with TB and concurrent DM (TBDM) at baseline, but the impact of TB treatment on this pattern has not been determined. We measured 17 plasma cytokines and growth factors in longitudinal cohorts of Indian and Brazilian pulmonary TB patients with or without DM. Principal component analysis revealed virtually complete separation of TBDM from TB individuals in both cohorts at baseline, with hyper-inflammation in TBDM that continued through treatment completion at six months. By one year after treatment completion, there was substantial convergence of mediator levels between groups within the India cohort. Non-resolving systemic inflammation in TBDM comorbidity could reflect delayed lesion sterilization or non-resolving sterile inflammation. Either mechanism portends unfavorable long-term outcomes including risk for recurrent TB and for damaging immune pathology.
Elife. 2019 Jul 4;8. pii: 46477. doi: 10.7554/eLife.46477. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/41125
RightsCopyright © 2019, Kumar et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright © 2019, Kumar et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
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