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dc.contributor.authorPiper, Andrew J.
dc.contributor.authorClark, Jennifer L
dc.contributor.authorMercado-Matos, Jose R.
dc.contributor.authorMatthew-Onabanjo, Asia N
dc.contributor.authorHsieh, Chung-Cheng
dc.contributor.authorAkalin, Ali
dc.contributor.authorShaw, Leslie M.
dc.date2022-08-11T08:09:54.000
dc.date.accessioned2022-08-23T16:47:56Z
dc.date.available2022-08-23T16:47:56Z
dc.date.issued2019-08-08
dc.date.submitted2019-09-19
dc.identifier.citation<p>PLoS One. 2019 Aug 8;14(8):e0220567. doi: 10.1371/journal.pone.0220567. eCollection 2019. <a href="https://doi.org/10.1371/journal.pone.0220567">Link to article on publisher's site</a></p>
dc.identifier.issn1932-6203 (Linking)
dc.identifier.doi10.1371/journal.pone.0220567
dc.identifier.pmid31393907
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41176
dc.description<p>Andrew Piper participated in this study as a medical student in the Senior Scholars research program at the University of Massachusetts Medical School.</p>
dc.description.abstractThe insulin-like growth factor-1 (IGF-1) signaling pathway has been implicated in non-small cell lung cancer (NSCLC) outcomes and resistance to targeted therapies. However, little is known regarding the molecular mechanisms by which this pathway contributes to the biology of NSCLC. The insulin receptor substrate (IRS) proteins are cytoplasmic adaptor proteins that signal downstream of the IGF-1R and determine the functional outcomes of this signaling pathway. In this study, we assessed the expression patterns of IRS-1 and IRS-2 in NSCLC to identify associations between IRS-1 and IRS-2 expression levels and survival outcomes in the two major histological subtypes of NSCLC, adenocarcinoma (ADC) and squamous cell carcinoma (SCC). High IRS-2 expression was significantly associated with decreased overall survival in adenocarcinoma (ADC) patients, whereas low IRS-1 cytoplasmic expression showed a trend toward association with decreased overall survival in squamous cell carcinoma (SCC) patients. Tumors with low IRS-1 and high IRS-2 expression were found to be associated with poor outcomes in ADC and SCC, indicating a potential role for IRS-2 in the aggressive behavior of NSCLC. Our results suggest distinct contributions of IRS-1 and IRS-2 to the biology of ADC and SCC that impact disease progression.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=31393907&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright: © 2019 Piper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdenocarcinomas
dc.subjectNon-small cell lung cancer
dc.subjectCytoplasmic staining
dc.subjectSquamous cell carcinomas
dc.subjectNuclear staining
dc.subjectMembrane staining
dc.subjectCell staining
dc.subjectLung and intrathoracic tumors
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectCancer Biology
dc.subjectCells
dc.subjectMolecular Biology
dc.subjectNeoplasms
dc.subjectOncology
dc.subjectPathology
dc.subjectRespiratory Tract Diseases
dc.subjectTherapeutics
dc.titleInsulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC)
dc.typeJournal Article
dc.source.journaltitlePloS one
dc.source.volume14
dc.source.issue8
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4980&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/3964
dc.identifier.contextkey15377578
refterms.dateFOA2022-08-23T16:47:57Z
html.description.abstract<p>The insulin-like growth factor-1 (IGF-1) signaling pathway has been implicated in non-small cell lung cancer (NSCLC) outcomes and resistance to targeted therapies. However, little is known regarding the molecular mechanisms by which this pathway contributes to the biology of NSCLC. The insulin receptor substrate (IRS) proteins are cytoplasmic adaptor proteins that signal downstream of the IGF-1R and determine the functional outcomes of this signaling pathway. In this study, we assessed the expression patterns of IRS-1 and IRS-2 in NSCLC to identify associations between IRS-1 and IRS-2 expression levels and survival outcomes in the two major histological subtypes of NSCLC, adenocarcinoma (ADC) and squamous cell carcinoma (SCC). High IRS-2 expression was significantly associated with decreased overall survival in adenocarcinoma (ADC) patients, whereas low IRS-1 cytoplasmic expression showed a trend toward association with decreased overall survival in squamous cell carcinoma (SCC) patients. Tumors with low IRS-1 and high IRS-2 expression were found to be associated with poor outcomes in ADC and SCC, indicating a potential role for IRS-2 in the aggressive behavior of NSCLC. Our results suggest distinct contributions of IRS-1 and IRS-2 to the biology of ADC and SCC that impact disease progression.</p>
dc.identifier.submissionpathoapubs/3964
dc.contributor.departmentSenior Scholars Program
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDepartment of Molecular, Cell and Cancer Biology
dc.source.pagese0220567


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Copyright: © 2019 Piper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright: © 2019 Piper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.