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    Transplantation of Renal Allograft After Removal of Renal Cell Carcinoma: Case Report and Review of the Literature

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    Authors
    Tran, Anthony P.
    Martins, Paulo N.A.
    Papazian, Zachary G.
    Vanguri, Vijay K.
    Movahedi, Babak
    Fan, Pang-Yen
    Bodziak, Kenneth A.
    Yates, Jennifer K.
    Sokoloff, Mitchell H.
    Bozorgzadeh, Adel
    UMass Chan Affiliations
    Department of Urology
    Department of Medicine, Division of Renal Medicine/Nephrology
    Department of Pathology
    Department of Surgery, Division of Organ Transplantation
    Document Type
    Journal Article
    Publication Date
    2019-10-01
    Keywords
    Kidney transplantation
    Kidney masses
    Living donor
    Female Urogenital Diseases and Pregnancy Complications
    Male Urogenital Diseases
    Neoplasms
    Nephrology
    Surgery
    Surgical Procedures, Operative
    Urogenital System
    Urology
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    Abstract
    With the rising incidence of end-stage renal disease in the United States, patients needing renal transplants are waiting longer for increasingly scarce grafts. Formerly, the general practice was to avoid organs with tumors for transplant because of the risk of malignancy transmission to the recipient. However, with comprehensive donor selection and a small-sized primary tumor, the positive outcomes of transplant outweigh the risks of transmission after a partial nephrectomy. In our case, a 31-year-old woman, the daughter of the recipient, underwent a laparoscopic nephrectomy with an existing 8-mm tumor later confirmed as renal cell carcinoma. An ex vivo tumor enucleation was performed before the allograft was transplanted into the 69-year-old patient with endstage renal disease. At last follow-up, graft function has remained excellent with no evidence of local recurrence or metastasis in both the donor and recipient. Here, we describe our case and perform a literature review on the incidence and management of renal allografts with incidentally detected renal cell carcinoma during transplant.
    Source

    Exp Clin Transplant. 2019 Oct 1. doi: 10.6002/ect.2018.0215. [Epub ahead of print] Link to article on publisher's site

    DOI
    10.6002/ect.2018.0215
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/41191
    PubMed ID
    31580237
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    Copyright © Baskent University 2019
    ae974a485f413a2113503eed53cd6c53
    10.6002/ect.2018.0215
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