Transplantation of Renal Allograft After Removal of Renal Cell Carcinoma: Case Report and Review of the Literature
AuthorsTran, Anthony P.
Martins, Paulo N.A.
Papazian, Zachary G.
Vanguri, Vijay K.
Bodziak, Kenneth A.
Yates, Jennifer K.
Sokoloff, Mitchell H.
UMass Chan AffiliationsDepartment of Urology
Department of Medicine, Division of Renal Medicine/Nephrology
Department of Pathology
Department of Surgery, Division of Organ Transplantation
Document TypeJournal Article
Female Urogenital Diseases and Pregnancy Complications
Male Urogenital Diseases
Surgical Procedures, Operative
MetadataShow full item record
AbstractWith the rising incidence of end-stage renal disease in the United States, patients needing renal transplants are waiting longer for increasingly scarce grafts. Formerly, the general practice was to avoid organs with tumors for transplant because of the risk of malignancy transmission to the recipient. However, with comprehensive donor selection and a small-sized primary tumor, the positive outcomes of transplant outweigh the risks of transmission after a partial nephrectomy. In our case, a 31-year-old woman, the daughter of the recipient, underwent a laparoscopic nephrectomy with an existing 8-mm tumor later confirmed as renal cell carcinoma. An ex vivo tumor enucleation was performed before the allograft was transplanted into the 69-year-old patient with endstage renal disease. At last follow-up, graft function has remained excellent with no evidence of local recurrence or metastasis in both the donor and recipient. Here, we describe our case and perform a literature review on the incidence and management of renal allografts with incidentally detected renal cell carcinoma during transplant.
Exp Clin Transplant. 2019 Oct 1. doi: 10.6002/ect.2018.0215. [Epub ahead of print] Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/41191
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