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Authors
Koupenova-Zamor, MilkaMick, Eric O.
Corkrey, Heather A.
Singh, Anupama
Tanriverdi, Selim E.
Vitseva, Olga
Levy, Daniel
Keeler, Allison M.
Ezzaty Mirhashemi, Marzieh
Elmallah, Mai K.
Gerstein, Mark
Rozowsky, Joel
Tanriverdi, Kahraman
Freedman, Jane E.
UMass Chan Affiliations
Horae Gene Therapy CenterDepartment of Pediatrics, Division of Pulmonary Medicine
Department of Population and Quantitative Health Sciences
Department of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2019-09-27Keywords
Biological SciencesMolecular Biology
Omics
Transcriptomics
Cardiovascular Diseases
Genetics and Genomics
Molecular Biology
Nucleic Acids, Nucleotides, and Nucleosides
Population Biology
Respiratory System
Respiratory Tract Diseases
Metadata
Show full item recordAbstract
The presence of nonhuman RNAs in man has been questioned and it is unclear if food-derived miRNAs cross into the circulation. In a large population study, we found nonhuman miRNAs in plasma by RNA sequencing and validated a small number of pine-pollen miRNAs by RT-qPCR in 2,776 people. The presence of these pine-pollen miRNAs associated with hay fever and not with overt cardiovascular or pulmonary disease. Using in vivo and in vitro models, we found that transmission of pollen-miRNAs into the circulation occurs via pulmonary transfer and this transfer was mediated by platelet-pulmonary vascular cell interactions and platelet pollen-DNA uptake. These data demonstrate that pollen-derived plant miRNAs can be horizontally transferred into the circulation via the pulmonary system in humans. Although these data suggest mechanistic plausibility for pulmonary-mediated plant-derived miRNA transfer into the human circulation, our large observational cohort data do not implicate major disease or risk factor association.Source
iScience. 2019 Sep 27;19:916-926. doi: 10.1016/j.isci.2019.08.035. Epub 2019 Aug 24. Link to article on publisher's site
DOI
10.1016/j.isci.2019.08.035Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41196PubMed ID
31518900Related Resources
Rights
Copyright 2019 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.isci.2019.08.035
Scopus Count
Except where otherwise noted, this item's license is described as Copyright 2019 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).