Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
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Authors
Goundan, Poorani NallamWillard, Devina Luhur
Sahin-Efe, Ayse
Fan, Shu-Ling Liang
Alexanian, Sara Michelle
UMass Chan Affiliations
Department of Pathology, UMass Memorial Medical CenterDocument Type
Journal ArticlePublication Date
2019-08-16Keywords
diabetic ketoacidosisdiagnosis
bicarbonate values
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Endocrine System Diseases
Endocrinology, Diabetes, and Metabolism
Nutritional and Metabolic Diseases
Pathology
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Objective: To determine if bicarbonate values from venous blood gas (VBG) and plasma chemistry samples provided agreement in determining the bicarbonate criteria for the diagnosis and/or resolution of diabetic ketoacidosis (DKA). Methods: A retrospective chart review of data from patients admitted to a tertiary care hospital with a diagnosis of DKA over a four year period was performed. Paired bicarbonate values from a VBG and chemistry panel, if drawn within 60minutes of each other, were compared. Results: At the time of diagnosis of DKA, 197 paired bicarbonate values were available for analysis with the mean difference between the two methods of testing of 2.5mmol/L. 16 of the 197 (8%) paired values were discordant in meeting criteria for diagnosis of DKA. At the time of resolution of DKA, 83 paired bicarbonate samples were compared. The mean difference was 2.3mmol/L. 20 of the 83 (24%) paired bicarbonate values showed discordance with regards to meeting the bicarbonate criteria for resolution of DKA. Conclusion: Discordance between bicarbonate results from different analysis methods may lead to different determinations as to whether or not a patient meets the biochemical definition for diagnosis and resolution of DKA.Source
J Clin Transl Endocrinol. 2019 Aug 16;18:100205. doi: 10.1016/j.jcte.2019.100205. eCollection 2019 Dec. Link to article on publisher's site
DOI
10.1016/j.jcte.2019.100205Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41197PubMed ID
31508318Related Resources
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© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.jcte.2019.100205
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Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/BY-NC-ND/4.0/).