Show simple item record

dc.contributor.authorSchoenfeld, Thomas A.
dc.contributor.authorCleland, Thomas A.
dc.date2022-08-11T08:09:54.000
dc.date.accessioned2022-08-23T16:48:04Z
dc.date.available2022-08-23T16:48:04Z
dc.date.issued2005-12-13
dc.date.submitted2008-06-18
dc.identifier.citationChem Senses. 2006 Feb;31(2):131-44. Epub 2005 Dec 8. <a href="http://dx.doi.org/10.1093/chemse/bjj015">Link to article on publisher's site</a>
dc.identifier.issn0379-864X (Print)
dc.identifier.doi10.1093/chemse/bjj015
dc.identifier.pmid16339266
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41202
dc.description.abstractOdorant sampling behaviors such as sniffing bring odorant molecules into contact with olfactory receptor neurons (ORNs) to initiate the sensory mechanisms of olfaction. In rodents, inspiratory airflow through the nose is structured and laminar; consequently, the spatial distribution of adsorbed odorant molecules during inspiration is predictable. Physicochemical properties such as water solubility and volatility, collectively called sorptiveness, interact with behaviorally regulable variables such as inspiratory flow rate to determine the pattern of odorant deposition along the inspiratory path. Populations of ORNs expressing the same odorant receptor are distributed in strictly delimited regions along this inspiratory path, enabling different deposition patterns of the same odorant to evoke different patterns of neuronal activation across the olfactory epithelium and in the olfactory bulb. We propose that both odorant sorptive properties and the regulation of sniffing behavior may contribute to rodents' olfactory capacities by this mechanism. In particular, we suggest that the motor regulation of sniffing behavior is substantially utilized for purposes of "zonation" or the direction of odorant molecules to defined intranasal regions and hence toward distinct populations of receptor neurons, pursuant to animals' sensory goals.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16339266&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1093/chemse/bjj015
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subject*Odors
dc.subjectOlfactory Bulb
dc.subjectOlfactory Receptor Neurons
dc.subjectRodentia
dc.subjectSmell
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleAnatomical contributions to odorant sampling and representation in rodents: zoning in on sniffing behavior
dc.typeJournal Article
dc.source.journaltitleChemical senses
dc.source.volume31
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/399
dc.identifier.contextkey533111
html.description.abstract<p>Odorant sampling behaviors such as sniffing bring odorant molecules into contact with olfactory receptor neurons (ORNs) to initiate the sensory mechanisms of olfaction. In rodents, inspiratory airflow through the nose is structured and laminar; consequently, the spatial distribution of adsorbed odorant molecules during inspiration is predictable. Physicochemical properties such as water solubility and volatility, collectively called sorptiveness, interact with behaviorally regulable variables such as inspiratory flow rate to determine the pattern of odorant deposition along the inspiratory path. Populations of ORNs expressing the same odorant receptor are distributed in strictly delimited regions along this inspiratory path, enabling different deposition patterns of the same odorant to evoke different patterns of neuronal activation across the olfactory epithelium and in the olfactory bulb. We propose that both odorant sorptive properties and the regulation of sniffing behavior may contribute to rodents' olfactory capacities by this mechanism. In particular, we suggest that the motor regulation of sniffing behavior is substantially utilized for purposes of "zonation" or the direction of odorant molecules to defined intranasal regions and hence toward distinct populations of receptor neurons, pursuant to animals' sensory goals.</p>
dc.identifier.submissionpathoapubs/399
dc.contributor.departmentDepartment of Physiology and Program in Neuroscience
dc.source.pages131-44


This item appears in the following Collection(s)

Show simple item record