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dc.contributor.authorDasgupta, Ishani
dc.contributor.authorMcCollum, Dannel
dc.date2022-08-11T08:09:54.000
dc.date.accessioned2022-08-23T16:48:13Z
dc.date.available2022-08-23T16:48:13Z
dc.date.issued2019-10-08
dc.date.submitted2019-11-12
dc.identifier.citation<p>J Biol Chem. 2019 Oct 8. pii: jbc.REV119.007963. doi: 10.1074/jbc.REV119.007963. [Epub ahead of print] <a href="https://doi.org/10.1074/jbc.REV119.007963" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn0021-9258 (Linking)
dc.identifier.doi10.1074/jbc.REV119.007963
dc.identifier.pmid31594864
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41230
dc.description.abstractTo perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These forces can be generated both internally and externally in response to physical properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells. Mechanical cues have important roles in cell fate decisions regarding proliferation, survival, differentiation as well as the processes of tissue regeneration and wound repair (1). Aberrant remodeling of the extracellular space and/or defects in properly responding to mechanical cues likely contributes to various disease states such as fibrosis, muscle diseases, and cancer (2). Mechanotransduction involves the sensing and translation of mechanical forces into biochemical signals, like activation of specific genes and signaling cascades that enable cells to adapt to their physical environment. The signaling pathways involved in mechanical signaling are highly complex, but numerous studies have highlighted a central role for the Hippo pathway and other signaling networks in regulating the YAP and TAZ (YAP/TAZ) proteins to mediate the effects of mechanical stimuli on cellular behavior. How mechanical cues control YAP/TAZ has been poorly understood. However, rapid progress in the last few years is beginning to reveal a surprisingly diverse set of pathways for controlling YAP/TAZ. In this review we will focus on how mechanical perturbations are sensed through changes in the actin cytoskeleton, and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=31594864&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsThis research was originally published in the Journal of Biological Chemistry. Ishani Dasgupta and Dannel McCollum, Control of cellular responses to mechanical cues through YAP/TAZ regulation. J. Biol. Chem. 2019. doi:10.1074/jbc.REV119.007963. © the Author(s). Accepted manuscript posted as allowed by publisher's copyright policy at http://www.jbc.org/site/misc/edpolicy.xhtml#copyright.
dc.subjectHippo pathway
dc.subjectLATS (Warts
dc.subjectWts)
dc.subjectTAZ
dc.subjectactin
dc.subjectadherens junction
dc.subjectcell signaling
dc.subjectfocal adhesions
dc.subjectmechanotransduction
dc.subjectyes-associated protein (YAP)
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectBiochemistry
dc.subjectBiological Phenomena, Cell Phenomena, and Immunity
dc.subjectCell Biology
dc.subjectCells
dc.subjectGenetic Phenomena
dc.titleControl of cellular responses to mechanical cues through YAP/TAZ regulation
dc.typeAccepted Manuscript
dc.source.journaltitleThe Journal of biological chemistry
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5031&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4014
dc.identifier.contextkey15758318
refterms.dateFOA2022-08-23T16:48:13Z
html.description.abstract<p>To perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These forces can be generated both internally and externally in response to physical properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells. Mechanical cues have important roles in cell fate decisions regarding proliferation, survival, differentiation as well as the processes of tissue regeneration and wound repair (1). Aberrant remodeling of the extracellular space and/or defects in properly responding to mechanical cues likely contributes to various disease states such as fibrosis, muscle diseases, and cancer (2). Mechanotransduction involves the sensing and translation of mechanical forces into biochemical signals, like activation of specific genes and signaling cascades that enable cells to adapt to their physical environment. The signaling pathways involved in mechanical signaling are highly complex, but numerous studies have highlighted a central role for the Hippo pathway and other signaling networks in regulating the YAP and TAZ (YAP/TAZ) proteins to mediate the effects of mechanical stimuli on cellular behavior. How mechanical cues control YAP/TAZ has been poorly understood. However, rapid progress in the last few years is beginning to reveal a surprisingly diverse set of pathways for controlling YAP/TAZ. In this review we will focus on how mechanical perturbations are sensed through changes in the actin cytoskeleton, and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ.</p>
dc.identifier.submissionpathoapubs/4014
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology


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